What determines nasal carriage of Staphylococcus aureus?

被引：250

作者：

Peacock, SJ

de Silva, I

Lowy, FD

机构：

[1] John Radcliffe Hosp, Dept Microbiol, Oxford OX3 9DU, England

[2] John Radcliffe Hosp, Nuffield Dept Clin Lab Sci, Oxford OX3 9DU, England

[3] Columbia Univ Coll Phys & Surg, Dept Med, Div Infect Dis, New York, NY 10032 USA

[4] Columbia Univ Coll Phys & Surg, Dept Med, Dept Pathol, New York, NY 10032 USA

来源：

TRENDS IN MICROBIOLOGY | 2001年 / 9卷 / 12期

关键词：

D O I：

10.1016/S0966-842X(01)02254-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Nasal carriage of Staphylococcus aureus is an important risk factor for infection by this organism in both community and hospital settings; this article reviews the role of host and bacterial factors in carriage. A host genetic influence appears likely but the phenotypic determinants are unknown. Possibilities include variability in host adhesins, immune response or secretion of antimicrobial molecules. Colonization resistance by S. aureus, together with the observation that persistent carriers often carry a single strain whereas intermittent carriers can be colonized with unrelated strains over time, suggests that bacterial factors could also be involved.

引用

页码：605 / 610

页数：6

共 75 条

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