The eosinophil enigma

被引：51

作者：

Williams, TJ ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Leukocyte Biol Sect, Div Biomed Sci, Sch Med, London SW7 2AZ, England

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2004年 / 113卷 / 04期

关键词：

D O I：

10.1172/JCI200421073

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Eosinophils accumulate in high numbers in the lungs of asthmatic patients. These cells have the ability to induce tissue damage, a capacity that relates to their traditional role in host defense against parasitic worms. On the other hand, eosinophils produce growth factors associated with tissue repair and remodeling, notably TGF-beta(1). The relationship of these activities to lung dysfunction in asthma is highly controversial, but recent observations in humans and in animal models add spice to the debate (see the related article beginning on page 551).

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页码：507 / 509

页数：3

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