ARIA: A neuromuscular junction neuregulin

被引：242

作者：

Fischbach, GD

Rosen, KM

机构：

[1] Department of Neurobiology, Harvard Medical School, Boston

来源：

ANNUAL REVIEW OF NEUROSCIENCE | 1997年 / 20卷

关键词：

D O I：

10.1146/annurev.neuro.20.1.429

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Motor neurons influence the expression and the distribution of acetylcholine receptors in skeletal muscle. Molecules that mediate this carefully choreographed interaction have recently been identified. One of them, ARIA, is a polypeptide purified from chicken brain on the basis of its ability to stimulate the synthesis of muscle acetylcholine receptors. The predicted amino acid sequence suggests that ARIA is synthesized as a transmembrane precursor protein and that it is a member of a family of ligands that activate receptor tyrosine kinases related to the epidermal growth factor receptor. Certain features of the ligand family (the neuregulins) and their receptors (erbBs) are reviewed. Evidence that ARIA plays an important role at developing and mature neuromuscular junctions is discussed.

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页码：429 / 458

页数：30

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