Trifluoromethylation of aryl and heteroaryl halides

被引:286
作者
Roy, Sudipta [1 ]
Gregg, Brian T. [1 ]
Gribble, Gordon W. [2 ]
Le, Van-Duc [1 ]
Roy, Sujata [1 ]
机构
[1] AMRI, Dept Med Chem, 26 Corp Circle, Albany, NY 12212 USA
[2] Dartmouth Coll, Dept Chem, Hanover, NH 03755 USA
关键词
CROSS-COUPLING REACTIONS; PHENYLETHANOLAMINE N-METHYLTRANSFERASE; FORMING REDUCTIVE ELIMINATION; ORGANIC FLUORINE-COMPOUNDS; NUCLEOPHILIC TRIFLUOROMETHYLATION; MEDICINAL CHEMISTRY; 1-AND 2-(TRIFLUOROMETHYL)NAPHTHALENES; BIOLOGICAL EVALUATION; SELECTIVE INHIBITORS; SYNTHETIC METHODS;
D O I
10.1016/j.tet.2011.01.002
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
[No abstract available]
引用
收藏
页码:2161 / 2195
页数:35
相关论文
共 212 条
  • [71] Organometallic chemistry of amidate complexes.: Accelerating effect of bidentate ligands on the reductive elimination of N-aryl amidates from palladium(II)
    Fujita, Ken-ichi
    Yamashita, Makoto
    Puschmann, Florian
    Alvarez-Falcon, Miguel Martinez
    Incarvito, Christopher D.
    Hartwig, John F.
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2006, 128 (28) : 9044 - 9045
  • [72] Penta-substituted benzimidazoles as potent antagonists of the calcium-sensing receptor (CaSR-antagonists)
    Gerspacher, Marc
    Altmann, Eva
    Beerli, Rene
    Buhl, Thomas
    Endres, Ralf
    Gamse, Rainer
    Kameni-Tcheudji, Jacques
    Kneissel, Michaela
    Krawinkler, Karl Heinz
    Missbach, Martin
    Schmidt, Alfred
    Seuwen, Klaus
    Weiler, Sven
    Widler, Leo
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2010, 20 (17) : 5161 - 5164
  • [73] Synthesis of α-trifluoromethylated nitrogen heterocycles
    Gille, S
    Ferry, A
    Billard, T
    Langlois, BR
    [J]. JOURNAL OF ORGANIC CHEMISTRY, 2003, 68 (23) : 8932 - 8935
  • [74] GLAXO LTD, 2006, Patent No. 2006040192
  • [75] PREDICTIVE STRUCTURE-ACTIVITY-RELATIONSHIPS IN A SERIES OF PYRANOQUINOLINE DERIVATIVES - A NEW PRIMATE MODEL FOR THE IDENTIFICATION OF ANTIALLERGIC ACTIVITY
    GOULD, KJ
    MANNERS, CN
    PAYLING, DW
    SUSCHITZKY, JL
    WELLS, E
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 1988, 31 (07) : 1445 - 1453
  • [76] Application of the Goldilocks Effect to the design of potent and selective inhibitors of phenylethanolamine N-methyltransferase:: Balancing pKa and steric effects in the optimization of 3-methyl-1,2,3,4-tetrahydroisoquinoline inhibitors by β-fluorination
    Grunewald, Gary L.
    Seim, Mitchell R.
    Lu, Jian
    Makboul, Mariam
    Criscione, Kevin R.
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 2006, 49 (10) : 2939 - 2952
  • [77] Inhibitors of phenylethanolamine N-methyltransferase devoid of α2-adrenoceptor affinity
    Grunewald, GL
    Lu, J
    Criscione, KR
    Moro, CO
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2005, 15 (23) : 5319 - 5323
  • [78] Facile Ar-CF3 bond formation at Pd.: Strikingly different outcomes of reductive elimination from [(Ph3P)2Pd(CF3)Ph] and [(Xantphos)Pd(CF3)Ph]
    Grushin, Vladimir V.
    Marshall, William J.
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2006, 128 (39) : 12644 - 12645
  • [79] The Organometallic Fluorine Chemistry of Palladium and Rhodium: Studies toward Aromatic Fluorination
    Grushin, Vladimir V.
    [J]. ACCOUNTS OF CHEMICAL RESEARCH, 2010, 43 (01) : 160 - 171
  • [80] Unexpected H2O-induced Ar-X activation with trifluoromethylpalladium(II) aryls
    Grushin, VV
    Marshall, WJ
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2006, 128 (14) : 4632 - 4641