Taurine prevents ammonia-induced accumulation of cyclic GMP in rat striatum by interaction with GABAA and glycine receptors

被引:18
作者
Hilgier, W
Oja, SS
Saransaari, P
Albrecht, J
机构
[1] Polish Acad Sci, Med Res Ctr, Dept Neurotoxicol, PL-02106 Warsaw, Poland
[2] Univ Tampere, Sch Med, Brain Res Ctr, FIN-33101 Tampere, Finland
[3] Tampere Univ Hosp, Dept Clin Physiol, Tampere, Finland
基金
芬兰科学院;
关键词
ammonia; taurine; striatum; GABAA receptor; glycine receptor; cyclic GMP;
D O I
10.1016/j.brainres.2005.02.066
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Previously, we had shown that ammonium chloride (ammonia)-induced accumulation of cyclic GMP in the microdialysates of rat striatum is blocked by taurine. In this study, coinfusion with taurine of a GABAA receptor antagonist bicuculline or a glycine receptor antagonist strychnine (100 mu M each), separately, restored ammonia-induced release of cGMP to the extracellular fluid to similar to 29% and 18% of the level measured in the absence of taurine, respectively. Simultaneous coinfusion of both antagonists or of 100 mu M picrotoxin, which is an antagonist of both GABAA and Gly receptors, offsets most of the taurine block. Ammonia-induced accumulation of cyclic GMP was attenuated by similar to 12% upon coinfusion of a GABAA receptor agonist muscimol (100 mu M). The results suggest that stimulation of both GABAA and glycine receptors is involved in the mechanism by which taurine limits the activation of the NMDA/NO/cGMP pathway by ammonia in the striatum. (c) 2005 Elsevier B.V. All rights reserved.
引用
收藏
页码:242 / 246
页数:5
相关论文
共 22 条
[11]   Taurine activates strychnine-sensitive glycine receptors in neurons freshly isolated from nucleus accumbens of young rats [J].
Jiang, ZL ;
Krnjevic, K ;
Wang, FS ;
Ye, JH .
JOURNAL OF NEUROPHYSIOLOGY, 2004, 91 (01) :248-257
[12]   MODULATION OF THE GABA-BENZODIAZEPINE RECEPTOR COMPLEX BY TAURINE IN RAT-BRAIN MEMBRANES [J].
MALMINEN, O ;
KONTRO, P .
NEUROCHEMICAL RESEARCH, 1986, 11 (01) :85-94
[13]   Electrophysiological evidence for expression of glycine receptors in freshly isolated neurons from nucleus accumbens [J].
Martin, G ;
Siggins, GR .
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2002, 302 (03) :1135-1145
[14]   β-alanine and taurine as endogenous agonists at glycine receptors in rat hippocampus in vitro [J].
Mori, M ;
Gähwiler, BH ;
Gerber, U .
JOURNAL OF PHYSIOLOGY-LONDON, 2002, 539 (01) :191-200
[15]   Taurine-induced attenuation of MPP+ neurotoxicity in vitro:: A possible role for the GABAA subclass of GABA receptors [J].
O'Byrne, MB ;
Tipton, KF .
JOURNAL OF NEUROCHEMISTRY, 2000, 74 (05) :2087-2093
[16]   Taurine and neural cell damage [J].
Saransaari, P ;
Oja, SS .
AMINO ACIDS, 2000, 19 (3-4) :509-526
[17]   Distribution of the major γ-iminobutyric acidA receptor subunits in the basal ganglia and associated limbic brain areas of the adult rat [J].
Schwarzer, C ;
Berresneim, U ;
Pirker, S ;
Wieselthaler, A ;
Fuchs, K ;
Sieghart, W ;
Sperk, G .
JOURNAL OF COMPARATIVE NEUROLOGY, 2001, 433 (04) :526-549
[18]   Expression and function of glycine receptors in striatal cholinergic interneurons from rat and mouse [J].
Sergeeva, OA ;
Haas, HL .
NEUROSCIENCE, 2001, 104 (04) :1043-1055
[19]  
SIEGHART W, 2001, J COMP NEUROL, V433, P526
[20]   Inhibitory interactions between spiny projection neurons in the rat striatum [J].
Tunstall, MJ ;
Oorschot, DE ;
Kean, A ;
Wickens, JR .
JOURNAL OF NEUROPHYSIOLOGY, 2002, 88 (03) :1263-1269