Androgen therapy in chronic renal failure

被引:20
作者
Handelsman, DJ [1 ]
Liu, PY [1 ]
机构
[1] Univ Sydney, Royal Prince Alfred Hosp, Dept Med, Androl Unit, Sydney, NSW 2006, Australia
来源
BAILLIERES CLINICAL ENDOCRINOLOGY AND METABOLISM | 1998年 / 12卷 / 03期
关键词
testosterone; androgens; chronic renal failure; renal transplant; anaemia; impotence; delayed puberty; erythropoietin; inhibin; clomiphene; hCG;
D O I
10.1016/S0950-351X(98)80248-6
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Chronic renal failure, dialysis and transplantation have major effects on male reproductive health because of the impairment of spermatogenesis, steroidogenesis and sexual function. Hypothalamo-pituitary testicular dysfunction in uraemia is manifest clinically as delayed growth and puberty, sexual dysfunction, androgen deficiency, impaired spermatogenesis and infertility. Apart from renal anaemia, there are at present no proven indications for androgen therapy in chronic renal failure. This chapter reviews the basis and scope for various clinical applications of gonadotropin and androgen therapy as an adjunct to the standard medical care of chronic renal failure. The therapeutic possibilities implied by experimental and clinical findings suggesting that uraemic hypogonadism may be a functional state of gonadotropin deficiency are emphasized.
引用
收藏
页码:485 / 500
页数:16
相关论文
共 79 条
[51]   CYCLOSPORINE-INDUCED ALTERATIONS IN THE HYPOTHALAMIC HYPOPHYSEAL GONADAL AXIS IN TRANSPLANT PATIENTS [J].
RAMIREZ, G ;
NARVARTE, J ;
BITTLE, PA ;
AYERSCHASTAIN, C ;
DEAN, SE .
NEPHRON, 1991, 58 (01) :27-32
[52]   OXANDROLONE FOR DELAYED PUBERTY IN BOYS TAKING LONG-TERM STEROID-THERAPY FOR RENAL-DISEASE [J].
REES, L ;
GREENE, SA ;
RIGDEN, SPA ;
HAYCOCK, GB ;
CHANTLER, C ;
PREECE, MA .
PEDIATRIC NEPHROLOGY, 1990, 4 (02) :160-162
[53]   LOSS OF PULSATILE LUTEINIZING-HORMONE SECRETION IN MEN WITH CHRONIC RENAL-FAILURE [J].
RODGER, RSC ;
MORRISON, L ;
DEWAR, JH ;
WILKINSON, R ;
WARD, MK ;
KERR, DNS .
BRITISH MEDICAL JOURNAL, 1985, 291 (6509) :1598-1600
[54]   OBSTRUCTIVE SLEEP-APNEA SYNDROME INDUCED BY TESTOSTERONE ADMINISTRATION [J].
SANDBLOM, RE ;
MATSUMOTO, AM ;
SCHOENE, RB ;
LEE, KA ;
GIBLIN, EC ;
BREMNER, WJ ;
PIERSON, DJ .
NEW ENGLAND JOURNAL OF MEDICINE, 1983, 308 (09) :508-510
[55]   PULSATILE IMMUNOREACTIVE AND BIOACTIVE LUTEINIZING-HORMONE SECRETION IN ADOLESCENTS WITH CHRONIC-RENAL-FAILURE [J].
SCHAEFER, F ;
SEIDEL, C ;
MITCHELL, R ;
SCHARER, K ;
ROBERTSON, WR .
PEDIATRIC NEPHROLOGY, 1991, 5 (04) :566-571
[56]   IMMUNOREACTIVE AND BIOACTIVE LUTEINIZING-HORMONE IN PUBERTAL PATIENTS WITH CHRONIC-RENAL-FAILURE [J].
SCHAEFER, F ;
VELDHUIS, JD ;
ROBERTSON, WR ;
DUNGER, D ;
SCHARER, K ;
BARRATT, TM ;
HAMILL, G ;
LEDERMAN, S ;
TROMPETER, RS ;
PERFUMO, F ;
REES, L ;
FINE, RN ;
RIGDEN, S ;
GEARY, D ;
POSTLETHWAITHE, R ;
MICHALK, D .
KIDNEY INTERNATIONAL, 1994, 45 (05) :1465-1476
[57]  
SCHAEFER RM, 1989, ERYTHROPOIETIN MOL S, P273
[58]  
Segarra A, 1996, NEPHRON, V73, P186
[59]   EFFECTS OF CYCLOSPORINE ON THE HYPOTHALAMIC-PITUITARY-GONADAL AXIS IN THE MALE-RAT - MECHANISM OF ACTION [J].
SIKKA, SC ;
BHASIN, S ;
COY, DC ;
KOYLE, MA ;
SWERDLOFF, RS ;
RAJFER, J .
ENDOCRINOLOGY, 1988, 123 (02) :1069-1074
[60]   PULSATILE BIOACTIVE LUTEINIZING-HORMONE SECRETION IN MEN WITH CHRONIC-RENAL-FAILURE AND FOLLOWING RENAL-TRANSPLANTATION [J].
TALBOT, JA ;
RODGER, RS ;
ROBERTSON, WR .
NEPHRON, 1990, 56 (01) :66-72