Construction of the azepinoindole Core Tricycle of the Stemona alkaloids

被引：62

作者：

Rigby, JH ^{[1
]}

Laurent, S ^{[1
]}

Cavezza, A ^{[1
]}

Heeg, MJ ^{[1
]}

机构：

[1] Wayne State Univ, Dept Chem, Detroit, MI 48202 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1998年 / 63卷 / 16期

关键词：

D O I：

10.1021/jo980916c

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The azepinoindole substructure common to a number of Stemona alkaloids is constructed by employing a 7-endo radical cyclization of a readily available N-alkylated hydroindolone substrate. The indolone precursors are prepared via [1 + 4] cycloaddition between a vinyl isocyanate and either dimethoxycarbene or cyclohexylisocyanide.

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页码：5587 / 5591

页数：5

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