Real sample analysis on microfluidic devices

被引:96
作者
Gonzalez Crevillen, Agustin [1 ]
Hervas, Miriam [1 ]
Angel Lopez, Miguel [1 ]
Cristina Gonzalez, Maria [1 ]
Escarpa, Alberto [1 ]
机构
[1] Univ Alcala de Henares, Dept Analyt Chem & Chem Engn, E-28871 Alcala De Henares, Spain
关键词
microfluidics; lab-on-a-chip; real sample analysis; clinical; environmental; food samples;
D O I
10.1016/j.talanta.2007.10.019
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
This review covers the state of the art of the analysis of real (or non-ideal) samples on microfluidic devices. A real sample analysis performed on microfluidics conceptually involves the complete integration of sample preparation, analyte separation, and detection on these platforms. Different "lab-on-a-chip" approaches have emerged in relevant application areas such as clinical, environmental, and food analysis which will be critically illustrated and discussed with respect to the strengths and weakness found. Likewise, the main challenges and perspectives will also be commented on. (c) 2007 Elsevier B.V. All rights reserved.
引用
收藏
页码:342 / 357
页数:16
相关论文
共 96 条
[1]   Rapid sample screening method for authenticity controlling vanilla flavors using a CE microchip approach with electrochemical detection [J].
Avila, Monica ;
Gonzalez, Maria Cristina ;
Zougagh, Mohammed ;
Escarpa, Alberto ;
Rios, Angel .
ELECTROPHORESIS, 2007, 28 (22) :4233-4239
[2]   Analysis of carboxylic acids in biological fluids by capillary electrophoresis [J].
Baena, B ;
Cifuentes, A ;
Barbas, C .
ELECTROPHORESIS, 2005, 26 (13) :2622-2636
[3]   Biochemical analysis with microfluidic systems [J].
Bilitewski, U ;
Genrich, M ;
Kadow, S ;
Mersal, G .
ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2003, 377 (03) :556-569
[4]   Fast and simultaneous detection of prominent natural antioxidants using analytical microsystems for capillary electrophoresis with a glassy carbon electrode:: A new gateway to food environments [J].
Blasco, AJ ;
Barrigas, I ;
González, MC ;
Escarpa, A .
ELECTROPHORESIS, 2005, 26 (24) :4664-4673
[5]   Electrochemical valveless flow microsystems for ultra fast and accurate analysis of total isoflavones with integrated calibration [J].
Blasco, Antonio Javier ;
Crevillen, Agustin Gonzalez ;
de la Fuente, Pedro ;
Gonzalez, Maria Cristina ;
Escarpa, Alberto .
ANALYST, 2007, 132 (04) :323-329
[6]   Isotachophoresis and isotachophoresis -: zone electrophoresis separations of inorganic anions present in water samples on a planar chip with column-coupling separation channels and conductivity detection [J].
Bodor, R ;
Madajová, V ;
Kaniansky, D ;
Masár, M ;
Jöhnck, M ;
Stanislawski, B .
JOURNAL OF CHROMATOGRAPHY A, 2001, 916 (1-2) :155-165
[7]   A microchip sensor for calcium determination [J].
Caglar, P. ;
Tuncel, S. A. ;
Malcik, N. ;
Landers, J. P. ;
Ferrance, J. P. .
ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2006, 386 (05) :1303-1312
[8]  
Ceriotti L, 2002, ELECTROPHORESIS, V23, P3615, DOI 10.1002/1522-2683(200210)23:20&lt
[9]  
3615::AID-ELPS3615&gt
[10]  
3.0.CO