Real sample analysis on microfluidic devices

被引:96
作者
Gonzalez Crevillen, Agustin [1 ]
Hervas, Miriam [1 ]
Angel Lopez, Miguel [1 ]
Cristina Gonzalez, Maria [1 ]
Escarpa, Alberto [1 ]
机构
[1] Univ Alcala de Henares, Dept Analyt Chem & Chem Engn, E-28871 Alcala De Henares, Spain
关键词
microfluidics; lab-on-a-chip; real sample analysis; clinical; environmental; food samples;
D O I
10.1016/j.talanta.2007.10.019
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
This review covers the state of the art of the analysis of real (or non-ideal) samples on microfluidic devices. A real sample analysis performed on microfluidics conceptually involves the complete integration of sample preparation, analyte separation, and detection on these platforms. Different "lab-on-a-chip" approaches have emerged in relevant application areas such as clinical, environmental, and food analysis which will be critically illustrated and discussed with respect to the strengths and weakness found. Likewise, the main challenges and perspectives will also be commented on. (c) 2007 Elsevier B.V. All rights reserved.
引用
收藏
页码:342 / 357
页数:16
相关论文
共 96 条
[51]  
Linder V, 2002, ELECTROPHORESIS, V23, P740, DOI 10.1002/1522-2683(200203)23:5<740::AID-ELPS740>3.0.CO
[52]  
2-7
[53]   Self-contained, fully integrated biochip for sample preparation, polymerase chain reaction amplification, and DNA microarray detection [J].
Liu, RH ;
Yang, JN ;
Lenigk, R ;
Bonanno, J ;
Grodzinski, P .
ANALYTICAL CHEMISTRY, 2004, 76 (07) :1824-1831
[54]   MINIATURIZED TOTAL CHEMICAL-ANALYSIS SYSTEMS - A NOVEL CONCEPT FOR CHEMICAL SENSING [J].
MANZ, A ;
GRABER, N ;
WIDMER, HM .
SENSORS AND ACTUATORS B-CHEMICAL, 1990, 1 (1-6) :244-248
[55]   Microfluidic devices for environmental monitoring [J].
Marle, L ;
Greenway, GM .
TRAC-TRENDS IN ANALYTICAL CHEMISTRY, 2005, 24 (09) :795-802
[56]   Do-it-yourself microelectrophoresis chips with integrated sample recovery [J].
Mohanty, Swomitra K. ;
Kim, Dongshin ;
Beebe, David J. .
ELECTROPHORESIS, 2006, 27 (19) :3772-3778
[57]   An integrated digital microfluidic chip for multiplexed proteomic sample preparation and analysis by MALDI-MS [J].
Moon, Hyejin ;
Wheeler, Aaron R. ;
Garrell, Robin L. ;
Loo, Joseph A. ;
Kim, Chang-Jin CJ'' .
LAB ON A CHIP, 2006, 6 (09) :1213-1219
[58]   Microfluidic tectonics platform: A colorimetric, disposable botulinum toxin enzyme-linked immunosorbent assay system [J].
Moorthy, J ;
Mensing, GA ;
Kim, D ;
Mohanty, S ;
Eddington, DT ;
Tepp, WH ;
Johnson, EA ;
Beebe, DJ .
ELECTROPHORESIS, 2004, 25 (10-11) :1705-1713
[59]   Indirect fluorescence detection of amino acids on electrophoretic microchips [J].
Munro, NJ ;
Huang, ZL ;
Finegold, DN ;
Landers, JP .
ANALYTICAL CHEMISTRY, 2000, 72 (13) :2765-2773
[60]   A compactly integrated flow cell with a chemiluminescent FIA system for determining lactate concentration in serum [J].
Nakamura, H ;
Murakami, Y ;
Yokoyama, K ;
Tamiya, E ;
Karube, I .
ANALYTICAL CHEMISTRY, 2001, 73 (02) :373-378