Real sample analysis on microfluidic devices

被引:96
作者
Gonzalez Crevillen, Agustin [1 ]
Hervas, Miriam [1 ]
Angel Lopez, Miguel [1 ]
Cristina Gonzalez, Maria [1 ]
Escarpa, Alberto [1 ]
机构
[1] Univ Alcala de Henares, Dept Analyt Chem & Chem Engn, E-28871 Alcala De Henares, Spain
关键词
microfluidics; lab-on-a-chip; real sample analysis; clinical; environmental; food samples;
D O I
10.1016/j.talanta.2007.10.019
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
This review covers the state of the art of the analysis of real (or non-ideal) samples on microfluidic devices. A real sample analysis performed on microfluidics conceptually involves the complete integration of sample preparation, analyte separation, and detection on these platforms. Different "lab-on-a-chip" approaches have emerged in relevant application areas such as clinical, environmental, and food analysis which will be critically illustrated and discussed with respect to the strengths and weakness found. Likewise, the main challenges and perspectives will also be commented on. (c) 2007 Elsevier B.V. All rights reserved.
引用
收藏
页码:342 / 357
页数:16
相关论文
共 96 条
[21]   CE microchips:: An opened gate to food analysis [J].
Escarpa, Alberto ;
Gonzalez, Maria Cristina ;
Crevillen, Agustin Gonzalez ;
Blasco, Antonio Javier .
ELECTROPHORESIS, 2007, 28 (06) :1002-1011
[22]  
Fanguy JC, 2002, ELECTROPHORESIS, V23, P767, DOI 10.1002/1522-2683(200203)23:5<767::AID-ELPS767>3.0.CO
[23]  
2-8
[24]   Membrane-based on-line optical analysis system for rapid detection of bacteria and spores [J].
Floriano, PN ;
Christodoulides, N ;
Romanovicz, D ;
Bernard, B ;
Simmons, GW ;
Cavell, M ;
McDevitt, JT .
BIOSENSORS & BIOELECTRONICS, 2005, 20 (10) :2079-2088
[25]   Macro-to-micro interfaces for microfluidic devices [J].
Fredrickson, CK ;
Fan, ZH .
LAB ON A CHIP, 2004, 4 (06) :526-533
[26]   Microchip separations of protein biotoxins using an integrated hand-held device [J].
Fruetel, JA ;
Renzi, RF ;
VanderNoot, VA ;
Stamps, J ;
Horn, BA ;
West, JAA ;
Ferko, S ;
Crocker, R ;
Bailey, CG ;
Arnold, D ;
Wiedenman, B ;
Choi, WY ;
Yee, D ;
Shokair, I ;
Hasselbrink, E ;
Paul, P ;
Rakestraw, D ;
Padgen, D .
ELECTROPHORESIS, 2005, 26 (06) :1144-1154
[27]   Fluorometric determination of sulrite and nitrite in aqueous samples using a novel detection unit of a microfluidic device [J].
Fujii, S ;
Tokuyama, T ;
Abo, M ;
Okubo, A .
ANALYTICAL SCIENCES, 2004, 20 (01) :209-212
[28]   Determination of levoglucosan from smoke samples using microchip capillary electrophoresis with pulsed amperometric detection [J].
García, CD ;
Engling, G ;
Herckes, P ;
Collett, JL ;
Henry, CS .
ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2005, 39 (02) :618-623
[29]   Direct detection of renal function markers using microchip CE with pulsed electrochemical detection [J].
Garcia, CD ;
Henry, CS .
ANALYST, 2004, 129 (07) :579-584
[30]   A fast and reliable route integrating calibration and analysis protocols for water-soluble vitamin determination on microchip-electrochemistry platforms [J].
Gonzalez Crevillen, Agustin ;
Javier Blasco, Antonio ;
Cristina Gonzalez, Maria ;
Escarpa, Alberto .
ELECTROPHORESIS, 2006, 27 (24) :5110-5118