The synthesis and transformations of 2-[2-ethoxycarbonyl-2-(2-pyridinyl)ethenyl]amino-3-dimethylaminopropenoates.: The synthesis of substituted β-amino-α,β-didehydro-α-amino acid derivatives

被引：5

作者：

Jukic, L

Recnik, S

Grdadolnik, SG

Svete, J

Stanovnik, B

机构：

[1] Univ Ljubljana, Fac Chem & Chem Technol, Ljubljana 1000, Slovenia

[2] Natl Inst Chem, Dept NMR & Mol Modelling, Ljubljana 1000, Slovenia

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2001年 / 38卷 / 04期

关键词：

D O I：

10.1002/jhet.5570380409

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Alkyl (Z)-2-[(E)-2-ethoxycarbonyl-2-(2-pyridinyl)ethenyl]amino-3-dimethylaminopropenoates 7 and 8 were prepared from ethyl 2-pyridinylacetate (1) in two steps. Substitution of the dimethylamino group with alkyl-, aryl-, or heteroarylamines afforded the corresponding beta -alkyl- 22-24, beta -aryl- 25-35, and beta -herteroaryl-amino-alpha,beta -didehydro-alpha -amino acid 36 and 37 derivatives, intermediates for further preparation of various heterocyclic systems. The orientation around both double bonds were determined by various nmr techniques.

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页码：859 / 868

页数：10

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