Novel 3-N-aminoglycoside acetyltransferase gene, aac(3)-Ic, from a Pseudomonas aeruginosa integron

被引：26

作者：

Riccio, ML

Docquier, JD

Dell'Amico, E

Luzzaro, F

Amicosante, G

Rossolini, GM ^{[1
]}

机构：

[1] Univ Siena, Dipartimento Biol Mol, Sez Microbiol, Policlin Le Scotte, I-53100 Siena, Italy

[2] Osped Circolo Varese, Microbiol Lab, I-21100 Varese, Italy

[3] Univ Aquila, Dipartimento Sci & Tecnol Biomed, I-67100 Laquila, Italy

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2003年 / 47卷 / 05期

关键词：

D O I：

10.1128/AAC.47.5.1746-1748.2003

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A novel gene, aac(3)-Ic, encoding an AAC(3)-I aminoglycoside 3-N-acetyltransferase, was identified on a gene cassette inserted into a Pseudomonas aeruginosa integron that also carries a bla(VIM-2) and a cml47 gene cassette. The aac(3)-Ic gene product is 59 and 57% identical to AAC(3)-Ia and AAC(3)-Ib, respectively, and confers resistance to gentamicin and sisomicin.

引用

页码：1746 / 1748

页数：3

共 22 条

[1] Oxacillinase-mediated resistance to cefepime and susceptibility to ceftazidime in Pseudomonas aeruginosa
Aubert, D
Poirel, L
Chevalier, J
Leotard, S
Pages, JM
Nordmann, P
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2001, 45 (06) : 1615 - 1620
[2] Bacterial resistance to aminoglycoside antibiotics
Davies, J
Wright, GD
[J]. TRENDS IN MICROBIOLOGY, 1997, 5 (06) : 234 - 240
[3] Docquier JD, 2001, EMERG INFECT DIS, V7, P910
[4] Molecular characterization of a novel class 1 integron containing blaGES-1 and a fused product of aac(3)-ib/Aac(6′)-Ib′ gene cassettes in Pseudomonas aeruginosa
Dubois, W
Poirel, L
Marie, C
Arpin, C
Nordmann, P
Quentin, C
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2002, 46 (03) : 638 - 645
[5] Efflux of chloramphenicol by the Cm1A1 protein
George, AM
Hall, RM
[J]. FEMS MICROBIOLOGY LETTERS, 2002, 209 (02) : 209 - 213
[6] IBC-1, a novel integron-associated class A β-lactamase with extended-spectrum properties produced by an Enterobacter cloacae clinical strain
Giakkoupi, P
Tzouvelekis, LS
Tsakris, A
Loukova, V
Sofianou, D
Tzelepi, E
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2000, 44 (09) : 2247 - 2253
[7] Nosocomial outbreak of carbapenem-resistant Pseudomonas aeruginosa with a new blaIMP allele, blaIMP-7
Gibb, AP
Tribuddharat, C
Moore, RA
Louie, TJ
Krulicki, W
Livermore, DM
Palepou, MFI
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2002, 46 (01) : 255 - 258
[8] Molecular characterization of integrons in epidemiologically unrelated clinical isolates of Acinetobacter baumannii from Italian hospitals reveals a limited diversity of gene cassette arrays
Gombac, F
Riccio, ML
Rossolini, GM
Lagatolla, C
Tonin, E
Monti-Bragadin, C
Lavenia, A
Dolzani, L
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2002, 46 (11) : 3665 - 3668
[9] The most frequent aminoglycoside resistance mechanisms - Changes with time and geographic area: A reflection of aminoglycoside usage patterns?
Miller, GH
Sabatelli, FJ
Hare, RS
Glupczynski, Y
Mackey, P
Shlaes, D
Shimizu, K
Shaw, KJ
Bauernfeind, A
Schweighart, S
Shannon, K
Patzer, J
Molinari, G
Schito, GC
GomezLus, R
GomezLus, S
Ferreira, H
Sousa, JC
Vaz, MJM
Collatz, E
Bismuth, R
Lambert, T
Courvalin, P
Minozzi, C
Klugman, K
Bilgeri, Y
Giamarellou, H
Petrikkos, G
Akalin, H
Gur, D
Woloj, M
Rossi, A
Casellas, J
Tokumoto, M
Couto, E
Juliet, C
Pinto, ME
Zemelman, R
Pedreira, W
Fernandez, M
Leal, I
Guzman, M
Murillo, J
Isturiz, P
Merentes, A
Bremner, A
Ho, B
Mayer, K
Ellal, J
Fu, W
[J]. CLINICAL INFECTIOUS DISEASES, 1997, 24 : S46 - S62
[10] Aminoglycosides: Activity and resistance
Mingeot-Leclercq, MP
Glupczynski, Y
Tulkens, PM
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1999, 43 (04) : 727 - 737

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