R spider: a network-based analysis of gene lists by combining signaling and metabolic pathways from Reactome and KEGG databases

被引：49

作者：

Antonov, Alexey V. ^{[1
]}

Schmidt, Esther E. ^{[2
]}

Dietmann, Sabine ^{[1
]}

Krestyaninova, Maria ^{[2
]}

Hermjakob, Henning ^{[2
]}

机构：

[1] German Res Ctr Environm Hlth GmbH, Helmholtz Zentrum Munchen, Inst Bioinformat & Syst Biol, D-85764 Neuherberg, Germany

[2] European Bioinformat Inst, Cambridge CB10 1SD, England

来源：

NUCLEIC ACIDS RESEARCH | 2010年 / 38卷

基金：

英国惠康基金; 美国国家卫生研究院;

关键词：

EXPRESSION DATA; ONTO-TOOLS;

D O I：

10.1093/nar/gkq482

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

R spider is a web-based tool for the analysis of a gene list using the systematic knowledge of core pathways and reactions in human biology accumulated in the Reactome and KEGG databases. R spider implements a network-based statistical framework, which provides a global understanding of gene relations in the supplied gene list, and fully exploits the Reactome and KEGG knowledge bases. R spider provides a user-friendly dialog-driven web interface for several model organisms and supports most available gene identifiers. R spider is freely available at http://mips.helmholtz-muenchen.de/proj/rspider.

引用

页码：W78 / W83

页数：6

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