Mouse Genome Database (MGD)-2018: knowledgebase for the laboratory mouse

被引:162
作者
Smith, Cynthia L. [1 ]
Blake, Judith A. [1 ]
Kadin, James A. [1 ]
Richardson, Joel E. [1 ]
Bult, Carol J. [1 ]
机构
[1] Jackson Lab, 600 Main St, Bar Harbor, ME 04609 USA
基金
美国国家卫生研究院;
关键词
PHENOTYPE ONTOLOGY; RESOURCE; MUTANTS; BIOLOGY;
D O I
10.1093/nar/gkx1006
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The Mouse Genome Database (MGD; http://www.informatics.jax.org) is the key community mouse database which supports basic, translational and computational research by providing integrated data on the genetics, genomics, and biology of the laboratory mouse. MGD serves as the source for biological reference data sets related to mouse genes, gene functions, phenotypes and disease models with an increasing emphasis on the association of these data to human biology and disease. We report here on recent enhancements to this resource, including improved access to mouse disease model and human phenotype data and enhanced relationships of mouse models to human disease.
引用
收藏
页码:D836 / D842
页数:7
相关论文
共 21 条
  • [1] OMIM.org: Online Mendelian Inheritance in Man (OMIM®), an online catalog of human genes and genetic disorders
    Amberger, Joanna S.
    Bocchini, Carol A.
    Schiettecatte, Francois
    Scott, Alan F.
    Hamosh, Ada
    [J]. NUCLEIC ACIDS RESEARCH, 2015, 43 (D1) : D789 - D798
  • [2] Mouse Genome Database (MGD)-2017: community knowledge resource for the laboratory mouse
    Blake, Judith A.
    Eppig, Janan T.
    Kadin, James A.
    Richardson, Joel E.
    Smith, Cynthia L.
    Bult, Carol J.
    [J]. NUCLEIC ACIDS RESEARCH, 2017, 45 (D1) : D723 - D729
  • [3] The mammalian gene function resource: the international knockout mouse consortium
    Bradley, Allan
    Anastassiadis, Konstantinos
    Ayadi, Abdelkader
    Battey, James F.
    Bell, Cindy
    Birling, Marie-Christine
    Bottomley, Joanna
    Brown, Steve D.
    Buerger, Antje
    Bult, Carol J.
    Bushell, Wendy
    Collins, Francis S.
    Desaintes, Christian
    Doe, Brendan
    Economides, Aris
    Eppig, Janan T.
    Finnell, Richard H.
    Fletcher, Colin
    Fray, Martin
    Frendewey, David
    Friedel, Roland H.
    Grosveld, Frank G.
    Hansen, Jens
    Herault, Yann
    Hicks, Geoffrey
    Hoerlein, Andreas
    Houghton, Richard
    de Angelis, Martin Hrabe
    Huylebroeck, Danny
    Iyer, Vivek
    de Jong, Pieter J.
    Kadin, James A.
    Kaloff, Cornelia
    Kennedy, Karen
    Koutsourakis, Manousos
    Lloyd, K. C. Kent
    Marschall, Susan
    Mason, Jeremy
    McKerlie, Colin
    McLeod, Michael P.
    von Melchner, Harald
    Moore, Mark
    Mujica, Alejandro O.
    Nagy, Andras
    Nefedov, Mikhail
    Nutter, Lauryl M.
    Pavlovic, Guillaume
    Peterson, Jane L.
    Pollock, Jonathan
    Ramirez-Solis, Ramiro
    [J]. MAMMALIAN GENOME, 2012, 23 (9-10) : 580 - 586
  • [4] ENU mutagenesis identifies the first mouse mutants reproducing human β-thalassemia at the genomic level
    Brown, Fiona C.
    Scott, Nicholas
    Rank, Gerhard
    Collinge, Janelle E.
    Vadolas, Jim
    Vickaryous, Nicola
    Whitelaw, Nadia
    Whitelaw, Emma
    Kile, Benjamin T.
    Jane, Stephen M.
    Curtis, David J.
    [J]. BLOOD CELLS MOLECULES AND DISEASES, 2013, 50 (02) : 86 - 92
  • [5] Mouse Tumor Biology (MTB): a database of mouse models for human cancer
    Bult, Carol J.
    Krupke, Debra M.
    Begley, Dale A.
    Richardson, Joel E.
    Neuhauser, Steven B.
    Sundberg, John P.
    Eppig, Janan T.
    [J]. NUCLEIC ACIDS RESEARCH, 2015, 43 (D1) : D818 - D824
  • [6] The diversity outbred mouse population
    Churchill, Gary A.
    Gatti, Daniel M.
    Munger, Steven C.
    Svenson, Karen L.
    [J]. MAMMALIAN GENOME, 2012, 23 (9-10) : 713 - 718
  • [7] An ENU mutagenesis screen identifies novel and known genes involved in epigenetic processes in the mouse
    Daxinger, Lucia
    Harten, Sarah K.
    Oey, Harald
    Epp, Trevor
    Isbel, Luke
    Huang, Edward
    Whitelaw, Nadia
    Apedaile, Anwyn
    Sorolla, Anabel
    Yong, Joan
    Bharti, Vandhana
    Sutton, Joanne
    Ashe, Alyson
    Pang, Zhenyi
    Wallace, Nathan
    Gerhardt, Daniel J.
    Blewitt, Marnie E.
    Jeddeloh, Jeffrey A.
    Whitelaw, Emma
    [J]. GENOME BIOLOGY, 2013, 14 (09):
  • [8] The International Mouse Strain Resource (IMSR): cataloging worldwide mouse and ES cell line resources
    Eppig, Janan T.
    Motenko, Howie
    Richardson, Joel E.
    Richards-Smith, Beverly
    Smith, Cynthia L.
    [J]. MAMMALIAN GENOME, 2015, 26 (9-10) : 448 - 455
  • [9] The Mouse Genome Database (MGD): facilitating mouse as a model for human biology and disease
    Eppig, Janan T.
    Blake, Judith A.
    Bult, Carol J.
    Kadin, James A.
    Richardson, Joel E.
    [J]. NUCLEIC ACIDS RESEARCH, 2015, 43 (D1) : D726 - D736
  • [10] The mouse Gene Expression Database (GXD): 2017 update
    Finger, Jacqueline H.
    Smith, Constance M.
    Hayamizu, Terry F.
    McCright, Ingeborg J.
    Xu, Jingxia
    Law, Meiyee
    Shaw, David R.
    Baldarelli, Richard M.
    Beal, Jon S.
    Blodgett, Olin
    Campbell, Jeff W.
    Corbani, Lori E.
    Lewis, Jill R.
    Forthofer, Kim L.
    Frost, Pete J.
    Giannatto, Sharon C.
    Hutchins, Lucie N.
    Miers, Dave B.
    Motenko, Howie
    Stone, Kevin R.
    Eppig, Janan T.
    Kadin, James A.
    Richardson, Joel E.
    Ringwald, Martin
    [J]. NUCLEIC ACIDS RESEARCH, 2017, 45 (D1) : D730 - D736