Disturbance and recovery of language function: correlates in PET activation studies

被引:95
作者
Heiss, WD
Thiel, A
Kessler, J
Herholz, K
机构
[1] Univ Cologne, Max Planck Inst Neurol Res, D-50931 Cologne, Germany
[2] Univ Cologne, Dept Neurol, D-50931 Cologne, Germany
关键词
D O I
10.1016/j.neuroimage.2003.09.005
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Disturbance of neurologic function in disorders of the central nervous system is expressed as an altered activation pattern in functional networks employed by specific tasks and can be studied by functional imaging modalities, e.g., positron emission tomography. Language, a complex brain function, is based on the interplay of a distributed network in which partial functions are executed in various centers, the primary language areas. These areas are hierarchically organized and activated according to the complexity of the specific language task. The specialization of different centers and the lateralization of integrative functions into the dominant (usually left) hemisphere are achieved by collateral and transcallosal inhibition of secondary language areas which normally are not employed for performance of a specific language task. (C) 2003 Elsevier Inc. All rights reserved.
引用
收藏
页码:S42 / S49
页数:8
相关论文
共 45 条
[31]  
NETZ J, 1995, EXP BRAIN RES, V104, P527
[32]   Neural substrates for the effects of rehabilitative training on motor recovery after ischemic infarct [J].
Nudo, RJ ;
Wise, BM ;
SiFuentes, F ;
Milliken, GW .
SCIENCE, 1996, 272 (5269) :1791-1794
[33]   Piracetam in the treatment of acute stroke [J].
Orgogozo, JM .
CNS DRUGS, 1998, 9 (Suppl 1) :41-49
[34]   Recovery of motor and language abilities after stroke: the contribution of functional imaging [J].
Rijntjes, M ;
Weiller, C .
PROGRESS IN NEUROBIOLOGY, 2002, 66 (02) :109-122
[35]   Neural correlates of recovery from aphasia after damage to left inferior frontal cortex [J].
Rosen, HJ ;
Petersen, SE ;
Linenweber, MR ;
Snyder, AZ ;
White, DA ;
Chapman, L ;
Dromerick, AW ;
Fiez, JA ;
Corbetta, M .
NEUROLOGY, 2000, 55 (12) :1883-1894
[36]   The ontogeny of cerebral language dominance [J].
Selnes, OA .
BRAIN AND LANGUAGE, 2000, 71 (01) :217-220
[37]   Motor cortical disinhibition in the unaffected hemisphere after unilateral cortical stroke [J].
Shimizu, Toshio ;
Hosaki, Akiko ;
Hino, Taro ;
Sato, Masaru ;
Komori, Tetsuo ;
Hirai, Shunsaku ;
Rossini, Paolo M. .
BRAIN, 2002, 125 :1896-1907
[38]   Plasticity of language networks in patients with brain tumors: A positron emission tomography activation study [J].
Thiel, A ;
Herholz, K ;
Koyuncu, A ;
Ghaemi, M ;
Kracht, LW ;
Habedank, B ;
Heiss, WD .
ANNALS OF NEUROLOGY, 2001, 50 (05) :620-629
[39]  
THIEL A, 2003, S CONV DIV LES STUD
[40]   Motor recovery after stroke: Lessons from functional brain imaging [J].
Thirumala, P ;
Hier, DB ;
Patel, P .
NEUROLOGICAL RESEARCH, 2002, 24 (05) :453-458