The ameliorating effect of the water layer of Fructus schisandrae on cycloheximide-induced amnesia in rats:: Interaction with drugs acting at neurotransmitter receptors

被引：24

作者：

Hsieh, MT ^{[1
]}

Wu, CR ^{[1
]}

Wang, WH ^{[1
]}

Lin, LW ^{[1
]}

机构：

[1] China Med Coll, Inst Chinese Pharmaceut Sci, Taichung 40421, Taiwan

来源：

PHARMACOLOGICAL RESEARCH | 2001年 / 43卷 / 01期

关键词：

Fructus Schisandra water layer; cycloheximide; passive avoidance task; rats;

D O I：

10.1006/phrs.2000.0756

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Our previous study indicated that the water layer present in Fructus Schisandra (FSW) at 10 and 25 mg kg(-1) significantly counteracted cycloheximide (CXM)-induced amnesia. Therefore, the mechanism of action of the ameliorating effect of FSW on CXM-induced amnesia in the passive avoidance task was investigated in rats. The ameliorating effect of FSW on CXM-induced amnesia was depressed by scopolamine. The serotonin releaser: p-chloroamphetamine significantly antagonized the ameliorating effect of FSW on CXM-induced amnesia. Furthermore, the ameliorating effect was also inhibited by the 5-HT1A receptor agonist 8-OH-DPAT, but potentiated by the 5-HT2 receptor antagonist ritanserin. Finally, the GABA(A) receptor antagonist bicuculline blocked the ameliorating effect of FSW. These results suggest that the beneficial effect of FSW on CXM-induced amnesia is amplified by treatment with serotonergic 5-HT2 receptor antagonists, but reduced by serotonergic 5-HT1A receptor agonists as well as GABA(A) and cholinergic receptor antagonists. (C) 2001 Academic Press.

引用

页码：17 / 22

页数：6

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