The ameliorating effect of the water layer of Fructus schisandrae on cycloheximide-induced amnesia in rats:: Interaction with drugs acting at neurotransmitter receptors

被引：24

作者：

Hsieh, MT ^{[1
]}

Wu, CR ^{[1
]}

Wang, WH ^{[1
]}

Lin, LW ^{[1
]}

机构：

[1] China Med Coll, Inst Chinese Pharmaceut Sci, Taichung 40421, Taiwan

来源：

PHARMACOLOGICAL RESEARCH | 2001年 / 43卷 / 01期

关键词：

Fructus Schisandra water layer; cycloheximide; passive avoidance task; rats;

D O I：

10.1006/phrs.2000.0756

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Our previous study indicated that the water layer present in Fructus Schisandra (FSW) at 10 and 25 mg kg(-1) significantly counteracted cycloheximide (CXM)-induced amnesia. Therefore, the mechanism of action of the ameliorating effect of FSW on CXM-induced amnesia in the passive avoidance task was investigated in rats. The ameliorating effect of FSW on CXM-induced amnesia was depressed by scopolamine. The serotonin releaser: p-chloroamphetamine significantly antagonized the ameliorating effect of FSW on CXM-induced amnesia. Furthermore, the ameliorating effect was also inhibited by the 5-HT1A receptor agonist 8-OH-DPAT, but potentiated by the 5-HT2 receptor antagonist ritanserin. Finally, the GABA(A) receptor antagonist bicuculline blocked the ameliorating effect of FSW. These results suggest that the beneficial effect of FSW on CXM-induced amnesia is amplified by treatment with serotonergic 5-HT2 receptor antagonists, but reduced by serotonergic 5-HT1A receptor agonists as well as GABA(A) and cholinergic receptor antagonists. (C) 2001 Academic Press.

引用

页码：17 / 22

页数：6

共 34 条

[21]

LEE L, 1996, CHIN J PHARM TOXICOL, V10, P92

[22] SIMILAR AMELIORATING EFFECTS OF BENZOMORPHANS AND 5-HT(2) ANTAGONISTS ON DRUG-INDUCED IMPAIRMENT OF PASSIVE-AVOIDANCE RESPONSE IN MICE - COMPARISON WITH ACETYLCHOLINESTERASE INHIBITORS [J].

MATSUNO, K ;

SENDA, T ;

MATSUNAGA, K ;

MITA, S ;

KANETO, H .

PSYCHOPHARMACOLOGY, 1993, 112 (01) :134-141

[23] Baclofen, a selective GABA(B) receptor agonist, dose-dependently impairs spatial learning in rats [J].

McNamara, RK ;

Skelton, RW .

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1996, 53 (02) :303-308

[24]

MENSESE A, 1994, PAHRM BIOCH BEHAV, V49, P1083

[25]

Molodtsova G. F., 1992, Byulleten' Eksperimental'noi Biologii i Meditsiny, V113, P342

[26] SEROTONIN-2 RECEPTOR-MEDIATED REGULATION OF RELEASE OF ACETYLCHOLINE BY MINAPRINE IN CHOLINERGIC NERVE-TERMINAL OF HIPPOCAMPUS OF RAT [J].

MURAMATSU, M ;

TAMAKIOHASHI, J ;

USUKI, C ;

ARAKI, H ;

AIHARA, H .

NEUROPHARMACOLOGY, 1988, 27 (06) :603-609

[27] ROLE OF CHOLINERGIC AND GABAERGIC NEURONAL SYSTEMS IN CYCLOHEXIMIDE-INDUCED AMNESIA IN MICE [J].

NABESHIMA, T ;

NODA, Y ;

ITOH, K ;

KAMEYAMA, T .

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1988, 31 (02) :405-409

[28]

NABESHIMA T, 1991, J PHARMACOL EXP THER, V257, P271

[29] EFFECTS OF 5-HT2 RECEPTOR ANTAGONIST ON CYCLOHEXIMIDE-INDUCED AMNESIA IN MICE [J].

NABESHIMA, T ;

ITOH, K ;

KAWASHIMA, K ;

KAMEYAMA, T .

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1989, 32 (03) :787-790

[30]

OGREN SO, 1986, BRAIN RES BULL, V16, P645

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