Cell-cycle regulation in immunity, tolerance and autoimmunity

被引:51
作者
Balomenos, D [1 ]
Martínez-A, C [1 ]
机构
[1] CSIC, Ctr Nacl Biotecnol, Dept Immunol & Oncol, E-28049 Madrid, Spain
来源
IMMUNOLOGY TODAY | 2000年 / 21卷 / 11期
关键词
D O I
10.1016/S0167-5699(00)01748-5
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
To trigger nn effective immune response, lymphocytes must proliferate. In addition to their direct involvement in cell-cycle progression, cell-cycle regulators might thus control immune functions. Recent evidence suggests that these regulators are essential for T-cell function; we argue that their study will provide cities for dissecting anergy and tolerance mechanisms, as well as for intervention in autoimmune diseases.
引用
收藏
页码:551 / 555
页数:5
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共 41 条
  • [31] G1 arrest and high expression of cyclin kinase and apoptosis inhibitors in accumulated activated memory phenotype CD4(+) cells of older lupus mice
    Sabzevari, H
    Propp, S
    Kono, DH
    Theofilopoulos, AN
    [J]. EUROPEAN JOURNAL OF IMMUNOLOGY, 1997, 27 (08) : 1901 - 1910
  • [32] CDK inhibitors:: positive and negative regulators of G1-phase progression
    Sherr, CJ
    Roberts, JM
    [J]. GENES & DEVELOPMENT, 1999, 13 (12) : 1501 - 1512
  • [33] SHERR CJ, 1996, SCIENCE, V274, P1671
  • [34] ENFORCED BCL2 EXPRESSION IN B-LYMPHOID CELLS PROLONGS ANTIBODY-RESPONSES AND ELICITS AUTOIMMUNE-DISEASE
    STRASSER, A
    WHITTINGHAM, S
    VAUX, DL
    BATH, ML
    ADAMS, JM
    CORY, S
    HARRIS, AW
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (19) : 8661 - 8665
  • [35] NOVEL PRIMITIVE LYMPHOID TUMORS INDUCED IN TRANSGENIC MICE BY COOPERATION BETWEEN MYC AND BCL-2
    STRASSER, A
    HARRIS, AW
    BATH, ML
    CORY, S
    [J]. NATURE, 1990, 348 (6299) : 331 - 333
  • [36] Aging impairs induction of cyclin-dependent kinases and down-regulation of p27 in mouse CD4+cells
    Tamir, A
    Miller, RA
    [J]. CELLULAR IMMUNOLOGY, 1999, 198 (01) : 11 - 20
  • [37] INVOLVEMENT OF THE BCL-2 GENE IN HUMAN FOLLICULAR LYMPHOMA
    TSUJIMOTO, Y
    COSSMAN, J
    JAFFE, E
    CROCE, CM
    [J]. SCIENCE, 1985, 228 (4706) : 1440 - 1443
  • [38] Molecules involved in cell death and peripheral tolerance
    Wang, J
    Lenardo, MJ
    [J]. CURRENT OPINION IN IMMUNOLOGY, 1997, 9 (06) : 818 - 825
  • [39] Aiolos regulates B cell activation and maturation to effector state
    Wang, JH
    Avitahl, N
    Cariappa, A
    Friedrich, C
    Ikeda, T
    Renold, A
    Andrikopoulos, K
    Liang, LB
    Pillai, S
    Morgan, BA
    Georgopoulos, K
    [J]. IMMUNITY, 1998, 9 (04) : 543 - 553
  • [40] Inteferon γ induces the expression of p21waf-1 and arrests macrophage cell cycle, preventing induction of apoptosis
    Xaus, J
    Cardó, M
    Valledor, AF
    Soler, C
    Lloberas, J
    Celada, A
    [J]. IMMUNITY, 1999, 11 (01) : 103 - 113