Layer-By-Layer Assembly of β-Estradiol Loaded Mesoporous Silica Nanoparticles on Titanium Substrates and Its Implication for Bone Homeostasis

被引：104

作者：

Hu, Yan ^{[1
]}

Cai, Kaiyong ^{[1
]}

Luo, Zhong ^{[1
]}

Jandt, Klaus D. ^{[2
]}

机构：

[1] Chongqing Univ, Key Lab Biorheol Sci & Technol, Minist Educ, Coll Bioengn, Chongqing 400044, Peoples R China

[2] Univ Jena, Inst Mat Sci & Technol, D-07743 Jena, Germany

来源：

ADVANCED MATERIALS | 2010年 / 22卷 / 37期

关键词：

CORE-SHELL STRUCTURE; DRUG-DELIVERY; GENE TRANSFECTION; SURFACE MODIFICATION; CONTROLLED-RELEASE; STEM-CELLS; IN-VITRO; GROWTH; DIFFERENTIATION; FILMS;

D O I：

10.1002/adma.201000854

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Drug-loading mesoporous silica nanoparticles that serve as a nanoreservoir-type drug-delivery system are successfully attached to titanium substrates via the layer-by-layer assembly technique (see scheme). The obtained structure demonstrates great potential for regulating the biological behaviors of osteoblasts/steoclasts in order to maintain bone homeostasis. The approach we present here may have wide applications in implant technology, tissue engineering, and regenerative medicine.

引用

页码：4146 / +

页数：6

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