Expression of a dendritic cell maturation marker CD83 on tumor cells from lung cancer patients and several human tumor cell lines: is there a biological meaning behind it?

被引：20

作者：

Baleeiro, R. B.

Bergami-Santos, P. C.

Tomiyoshi, M. Y.

Gross, J. L.

Haddad, F.

Pinto, C. A. L.

Soares, F. A.

Younes, R. N.

Barbuto, J. A. M.

机构：

[1] Univ Sao Paulo, Inst Biomed Sci, Dept Immunol, BR-05508000 Sao Paulo, SP, Brazil

[2] Canc Hosp AC Camargo, Treatment & Res Ctr, Dept Thorac Surg, BR-01509900 Sao Paulo, SP, Brazil

[3] Canc Hosp AC Camargo, Treatment & Res Ctr, Dept Pathol Anat, BR-01509900 Sao Paulo, SP, Brazil

来源：

CANCER IMMUNOLOGY IMMUNOTHERAPY | 2008年 / 57卷 / 02期

基金：

巴西圣保罗研究基金会;

关键词：

CD83; lung cancer; human tumor cell lines; cancer immunosuppression;

D O I：

10.1007/s00262-007-0344-x

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

The present paper shows, for the first time, the membrane expression of the dendritic cell maturation marker CD83 on tumor cells from lung cancer patients. CD83 was also detected on freshly cultured fibroblast-like cells from these tissues and on several adherent human tumor cell lines (lung adenocarcinomas P9, A459 and A549, melanomas A375 and C81-61, breast adenocarcinomas SKBR-3 and MCF-7 and colon carcinoma AR42-J), but not in the non-adherent MOT leukemia cell line. CD83 may have immunosuppressive properties and its expression by cancer cells could have a role in facilitating tumor growth.

引用

页码：265 / 270

页数：6

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