Design and synthesis of novel 20-epi analogues of calcitriol with restricted side chain conformation

被引：7

作者：

Fernández, C

Gómez, G

Lago, C

Momán, E

Fall, Y ^{[1
]}

机构：

[1] Univ Vigo, Fac Quim, Dept Quim Organ, Vigo 36200, Spain

[2] Royal Coll Surgeons Ireland, Dept Pharmaceut & Med Chem, Ctr Synth & Chem Biol, Dublin 2, Ireland

来源：

SYNLETT | 2005年 / 14期

关键词：

synthesis; vitamin D; analogues; nitriles; diols; drugs;

D O I：

10.1055/s-2005-872224

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The design and efficient preparation of two 20-epi analogues of calcitriol with restricted side chain conformation is described. The formation of the tetrahydropyran ring was achieved via zinc chloride mediated etherification of alcohols. Docking experiments show that these novel analogues could be interesting synthetic targets.

引用

收藏

页码：2163 / 2166

页数：4

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