Synthesis of fused heterocycles with a benzazepinone moiety via intramolecular Heck coupling

被引：56

作者：

Joucla, L ^{[1
]}

Putey, A ^{[1
]}

Joseph, B ^{[1
]}

机构：

[1] Univ Lyon 1, CNRS, UMR 5181, Lab Chim Organ 1, F-69622 Villeurbanne, France

来源：

TETRAHEDRON LETTERS | 2005年 / 46卷 / 47期

关键词：

benzazepinone; palladium; heck; cyclisation;

D O I：

10.1016/j.tetlet.2005.09.122

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The preparation of fused heterocycles with a benzazepinone moiety was realised via an intramolecular Heck coupling reaction either at position 2 or at position 3 of the heterocyclic system. This method allowed the synthesis of the pyrrolo[2,3-c]azepinone core and Paullone derivatives. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：8177 / 8179

页数：3

共 14 条

[11] Latonduines A and B, new alkaloids isolated from the marine sponge Stylissa carteri:: Structure elucidation, synthesis, and biogenetic implications [J].

Linington, RG ;

Williams, DE ;

Tahir, A ;

van Soest, R ;

Andersen, RJ .

ORGANIC LETTERS, 2003, 5 (15) :2735-2738

[12] Pharmacological inhibitors of glycogen synthase kinase 3 [J].

Meijer, L ;

Flajolet, M ;

Greengard, P .

TRENDS IN PHARMACOLOGICAL SCIENCES, 2004, 25 (09) :471-480

[13]

Mouaddib A, 2000, SYNTHESIS-STUTTGART, P549

[14] Paullones, a series of cyclin-dependent kinase inhibitors: Synthesis, evaluation of CDK1/cyclin B inhibition, and in vitro antitumor activity [J].

Schultz, C ;

Link, A ;

Leost, M ;

Zaharevitz, DW ;

Gussio, R ;

Sausville, EA ;

Meijer, L ;

Kunick, C .

JOURNAL OF MEDICINAL CHEMISTRY, 1999, 42 (15) :2909-2919

← 1 2 →