Combinatorial patterns of histone acetylations and methylations in the human genome

被引：1700

作者：

Wang, Zhibin ^{[1
]}

Zang, Chongzhi ^{[2
]}

Rosenfeld, Jeffrey A. ^{[3
]}

Schones, Dustin E. ^{[1
]}

Barski, Artem ^{[1
]}

Cuddapah, Suresh ^{[1
]}

Cui, Kairong ^{[1
]}

Roh, Tae-Young ^{[1
]}

Peng, Weiqun

Zhang, Michael Q. ^{[3
]}

Zhao, Keji ^{[1
]}

机构：

[1] NHLBI, Lab Mol Immunol, US NIH, Bethesda, MD 20892 USA

[2] George Washington Univ, Dept Phys, Washington, DC 20052 USA

[3] Cold Spring Harbor Lab, Cold Spring Harbor, NY 11724 USA

来源：

NATURE GENETICS | 2008年 / 40卷 / 07期

关键词：

D O I：

10.1038/ng.154

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Histones are characterized by numerous posttranslational modifications that influence gene transcription(1,2). However, because of the lack of global distribution data in higher eukaryotic systems(3), the extent to which gene-specific combinatorial patterns of histone modifications exist remains to be determined. Here, we report the patterns derived from the analysis of 39 histone modifications in human CD4(+) T cells. Our data indicate that a large number of patterns are associated with promoters and enhancers. In particular, we identify a common modification module consisting of 17 modifications detected at 3,286 promoters. These modifications tend to colocalize in the genome and correlate with each other at an individual nucleosome level. Genes associated with this module tend to have higher expression, and addition of more modifications to this module is associated with further increased expression. Our data suggest that these histone modifications may act cooperatively to prepare chromatin for transcriptional activation.

引用

页码：897 / 903

页数：7

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