Small molecules and chemical tools at the interface

被引:6
作者
Newman, Robert H. [1 ]
Zhang, Jin [1 ]
机构
[1] Johns Hopkins Univ, Sch Med, Dept Pharmacol & Mol Sci, Baltimore, MD 21205 USA
关键词
D O I
10.1038/nchembio0708-382
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
As our understanding of the molecular mechanisms driving complex biological processes grows, the role of chemical biology will continue to expand. The 2008 American Society for Biochemistry and Molecular Biology meeting showcased recent progress in the field of chemical biology while simultaneously pointing toward the future of research at the interface between chemistry and biology.
引用
收藏
页码:382 / 386
页数:5
相关论文
共 25 条
[1]   Reading dynamic kinase activity in living cells for high-throughput screening [J].
Allen, Michael D. ;
DiPilato, Lisa M. ;
Rahdar, Meghdad ;
Ren, Yunzhao R. ;
Chong, Curtis ;
Liu, Jun O. ;
Zhang, Jin .
ACS CHEMICAL BIOLOGY, 2006, 1 (06) :371-376
[2]   Light-activated ion channels for remote control of neuronal firing [J].
Banghart, M ;
Borges, K ;
Isacoff, E ;
Trauner, D ;
Kramer, RH .
NATURE NEUROSCIENCE, 2004, 7 (12) :1381-1386
[3]   Cation-π interactions in ligand recognition by serotonergic (5-HT3A) and nicotinic acetylcholine receptors:: The anomalous binding properties of nicotine [J].
Beene, DL ;
Brandt, GS ;
Zhong, WG ;
Zacharias, NM ;
Lester, HA ;
Dougherty, DA .
BIOCHEMISTRY, 2002, 41 (32) :10262-10269
[4]   T cell receptor microcluster transport through molecular mazes reveals mechanism of translocation [J].
DeMond, Andrew L. ;
Mossman, Kaspar D. ;
Starr, Toby ;
Dustin, Michael L. ;
Groves, Jay T. .
BIOPHYSICAL JOURNAL, 2008, 94 (08) :3286-3292
[5]   Modulation of bacterial quorum sensing with synthetic ligands:: Systematic evaluation of N-acylated homoserine lactones in multiple species and new insights into their mechanisms of action [J].
Geske, Grant D. ;
O'Neill, Jennifer C. ;
Miller, David M. ;
Mattmann, Margrith E. ;
Blackwell, Helen E. .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2007, 129 (44) :13613-13625
[6]   Mechanisms of photoswitch conjugation and light activation of an ionotropic glutamate receptor [J].
Gorostiza, Pau ;
Volgraf, Matthew ;
Numano, Rika ;
Szobota, Stephanie ;
Trauner, Dirk ;
Isacoff, Ehud Y. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (26) :10865-10870
[7]   Artery/vein specification is governed by opposing phosphatidylinositol-3 kinase and MAP kinase/ERK signaling [J].
Hong, Charles C. ;
Peterson, Quinn P. ;
Hong, Ji-Young ;
Peterson, Randall T. .
CURRENT BIOLOGY, 2006, 16 (13) :1366-1372
[8]   Cytotoxic ribonucleases: The dichotomy of coulombic forces [J].
Johnson, R. Jeremy ;
Chao, Tzu-Yuan ;
Lavis, Luke D. ;
Raines, Ronald T. .
BIOCHEMISTRY, 2007, 46 (36) :10308-10316
[9]   Inhibition of human pancreatic ribonuclease by the human ribonuclease inhibitor protein [J].
Johnson, R. Jeremy ;
McCoy, Jason G. ;
Bingman, Craig A. ;
Phillips, George N., Jr. ;
Raines, Ronald T. .
JOURNAL OF MOLECULAR BIOLOGY, 2007, 368 (02) :434-449
[10]   Fluorogenic label for biomolecular imaging [J].
Lavis, Luke D. ;
Chao, Tzu-Yuan ;
Raines, Ronald T. .
ACS CHEMICAL BIOLOGY, 2006, 1 (04) :252-260