Rapid liquid chromatography-tandem mass spectrometry method for the determination of a broad mixture of pharmaceuticals in surface water

被引:110
作者
Conley, Justin M. [1 ]
Symes, Steven J. [2 ]
Kindelberger, Scott A. [2 ]
Richards, Sean A. [1 ]
机构
[1] Univ Tennessee, Dept Biol & Environm Sci, Chattanooga, TN 37403 USA
[2] Univ Tennessee, Dept Chem, Chattanooga, TN 37403 USA
关键词
ultra performance liquid chromatography; solid-phase extraction; tandem mass spectrometry; environmental analysis; surface water; pharmaceutical; drug; matrix effect; standard addition;
D O I
10.1016/j.chroma.2008.01.064
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Herein, a new method for the detection of 13 different pharmaceuticals and one metabolite in surface water at low ng/L levels is described. The method utilizes ultra performance liquid chromatography-tandem mass spectrometry and a solid-phase extraction sample preparation. Mean method detection limits were low(4.10 ng/L and overall solid-phase extraction recovery and reproducibility was adequate (mean recovery, 77.9%; mean RSD, 7.3%). The method allows for quick run times and minimal solvent use as compared with other previously reported high performance liquid chromatography-based methods. Application of this method for the detection of pharmaceuticals in Tennessee River surface water determined that caffeine, sulfamethoxazole, and carbamazepine were frequently detected (100% of samples). Trimethoprim was moderately detected (30% of samples); acetaminophen, atorvastatin, and lovastatin were infrequently detected (10% of samples); and ciprofloxacin, diltiazem, fluoxetine, levofloxacin, norfluoxetine, ranitidine, and sertraline were not detected. This study reports the first detection of lovastatin in surface water. (C) 2008 Elsevier B.V. All rights reserved.
引用
收藏
页码:206 / 215
页数:10
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