Agonizing hedgehog

被引：17

作者：

Briscoe, J ^{[1
]}

机构：

[1] Natl Inst Med Res, Dept Dev Neurobiol, London NW7 1AA, England

来源：

NATURE CHEMICAL BIOLOGY | 2006年 / 2卷 / 01期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1038/nchembio0106-10

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Hedgehog signaling has important and pleiotropic roles in embryonic and adult tissues. A small-molecule agonist of this pathway has been shown to act by targeting the transmembrane protein Smoothened.

引用

页码：10 / 11

页数：3

共 10 条

[1]

Gli and hedgehog in cancer:: Tumours, embryos and stem cells [J].

Altaba, AR ;

Sánchez, P ;

Dahmane, N .

NATURE REVIEWS CANCER, 2002, 2 (05) :361-372

[2]

Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened [J].

Chen, JK ;

Taipale, J ;

Cooper, MK ;

Beachy, PA .

GENES & DEVELOPMENT, 2002, 16 (21) :2743-2748

[3]

Small molecule modulation of Smoothened activity [J].

Chen, JK ;

Taipale, J ;

Young, KE ;

Maiti, T ;

Beachy, PA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (22) :14071-14076

[4]

Vertebrate Smoothened functions at the primary cilium [J].

Corbit, KC ;

Aanstad, P ;

Singla, V ;

Norman, AR ;

Stainier, DYR ;

Reiter, JF .

NATURE, 2005, 437 (7061) :1018-1021

[5]

Frank-Kamenetsky Maria, 2002, J Biol, V1, P10, DOI 10.1186/1475-4924-1-10

[6]

Signaling from Smo to Ci/Gli:: conservation and divergence of Hedgehog pathways from Drosophila to vertebrates [J].

Huangfu, D ;

Anderson, KV .

DEVELOPMENT, 2006, 133 (01) :3-14

[7]

Purmorphamine activates the Hedgehog pathway by targeting Smoothened [J].

Sinha, S ;

Chen, JK .

NATURE CHEMICAL BIOLOGY, 2006, 2 (01) :29-30

[8]

Patched acts catalytically to suppress the activity of Smoothened [J].

Taipale, J ;

Cooper, MK ;

Maiti, T ;

Beachy, PA .

NATURE, 2002, 418 (6900) :892-897

[9]

Purmorphamine induces osteogenesis by activation of the hedgehog signaling pathway [J].

Wu, X ;

Walker, J ;

Zhang, J ;

Ding, S ;

Schultz, PG .

CHEMISTRY & BIOLOGY, 2004, 11 (09) :1229-1238

[10]

A small molecule with osteogenesis-inducing activity in multipotent mesenchymal progenitor cells [J].

Wu, X ;

Ding, S ;

Ding, Q ;

Gray, NS ;

Schultz, PG .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2002, 124 (49) :14520-14521

← 1 →