Fast-forward genetics enabled by new sequencing technologies

被引：147

作者：

Schneeberger, Korbinian ^{[1
,2
]}

Weigel, Detlef ^{[1
]}

机构：

[1] Max Planck Inst Dev Biol, Dept Mol Biol, D-72076 Tubingen, Germany

[2] Max Planck Inst Plant Breeding Res, Dept Plant Dev Biol, D-50829 Cologne, Germany

来源：

TRENDS IN PLANT SCIENCE | 2011年 / 16卷 / 05期

关键词：

GENOME-WIDE ASSOCIATION; ARABIDOPSIS-THALIANA; SHORT READS; DROSOPHILA-MELANOGASTER; MAPPING POPULATION; FLOWERING TIME; SNP DISCOVERY; RNA-SEQ; IDENTIFICATION; RESISTANCE;

D O I：

10.1016/j.tplants.2011.02.006

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

New sequencing technologies are dramatically accelerating progress in forward genetics, and the use of such methods for the rapid identification of mutant alleles will be soon routine in many laboratories. A straightforward extension will be the cloning of major-effect genetic variants in crop species. In the near future, it can be expected that mapping by sequencing will become a centerpiece in efforts to discover the genes responsible for quantitative trait loci. The largest impact, however, might come from the use of these strategies to extract genes from non-model, non-crop plants that exhibit heritable variation in important traits. Deployment of such genes to improve crops or engineer microbes that produce valuable compounds heralds a potential paradigm shift for plant biology.

引用

页码：282 / 288

页数：7

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