Fast-forward genetics enabled by new sequencing technologies

被引：147

作者：

Schneeberger, Korbinian ^{[1
,2
]}

Weigel, Detlef ^{[1
]}

机构：

[1] Max Planck Inst Dev Biol, Dept Mol Biol, D-72076 Tubingen, Germany

[2] Max Planck Inst Plant Breeding Res, Dept Plant Dev Biol, D-50829 Cologne, Germany

来源：

TRENDS IN PLANT SCIENCE | 2011年 / 16卷 / 05期

关键词：

GENOME-WIDE ASSOCIATION; ARABIDOPSIS-THALIANA; SHORT READS; DROSOPHILA-MELANOGASTER; MAPPING POPULATION; FLOWERING TIME; SNP DISCOVERY; RNA-SEQ; IDENTIFICATION; RESISTANCE;

D O I：

10.1016/j.tplants.2011.02.006

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

New sequencing technologies are dramatically accelerating progress in forward genetics, and the use of such methods for the rapid identification of mutant alleles will be soon routine in many laboratories. A straightforward extension will be the cloning of major-effect genetic variants in crop species. In the near future, it can be expected that mapping by sequencing will become a centerpiece in efforts to discover the genes responsible for quantitative trait loci. The largest impact, however, might come from the use of these strategies to extract genes from non-model, non-crop plants that exhibit heritable variation in important traits. Deployment of such genes to improve crops or engineer microbes that produce valuable compounds heralds a potential paradigm shift for plant biology.

引用

页码：282 / 288

页数：7

共 69 条

[11] Common sequence polymorphisms shaping genetic diversity in Arabidopsis thaliana [J].

Clark, Richard M. ;

Schweikert, Gabriele ;

Toomajian, Christopher ;

Ossowski, Stephan ;

Zeller, Georg ;

Shinn, Paul ;

Warthmann, Norman ;

Hu, Tina T. ;

Fu, Glenn ;

Hinds, David A. ;

Chen, Huaming ;

Frazer, Kelly A. ;

Huson, Daniel H. ;

Schoelkopf, Bernhard ;

Nordborg, Magnus ;

Raetsch, Gunnar ;

Ecker, Joseph R. ;

Weigel, Detlef .

SCIENCE, 2007, 317 (5836) :338-342

[12] TILLING: practical single-nucleotide mutation discovery [J].

Comai, L ;

Henikoff, S .

PLANT JOURNAL, 2006, 45 (04) :684-694

[13]

Craig DW, 2008, NAT METHODS, V5, P887, DOI [10.1038/nmeth.1251, 10.1038/NMETH.1251]

[14] Multiplex sequencing of plant chloroplast genomes using Solexa sequencing-by-synthesis technology [J].

Cronn, Richard ;

Liston, Aaron ;

Parks, Matthew ;

Gernandt, David S. ;

Shen, Rongkun ;

Mockler, Todd .

NUCLEIC ACIDS RESEARCH, 2008, 36 (19)

[15] A genome-wide view of Caenorhabditis elegans base-substitution mutation processes [J].

Denver, Dee R. ;

Dolan, Peter C. ;

Wilhelm, Larry J. ;

Sung, Way ;

Lucas-Lledo, J. Ignacio ;

Howe, Dana K. ;

Lewis, Samantha C. ;

Okamoto, Kazu ;

Thomas, W. Kelley ;

Lynch, Michael ;

Baer, Charles F. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (38) :16310-16314

[16] C. elegans Mutant Identification with a One-Step Whole-Genome-Sequencing and SNP Mapping Strategy [J].

Doitsidou, Maria ;

Poole, Richard J. ;

Sarin, Sumeet ;

Bigelow, Henry ;

Hobert, Oliver .

PLOS ONE, 2010, 5 (11)

[17] Dissection of genetically complex traits with extremely large pools of yeast segregants [J].

Ehrenreich, Ian M. ;

Torabi, Noorossadat ;

Jia, Yue ;

Kent, Jonathan ;

Martis, Stephen ;

Shapiro, Joshua A. ;

Gresham, David ;

Caudy, Amy A. ;

Kruglyak, Leonid .

NATURE, 2010, 464 (7291) :1039-U101

[18] High-quality draft assemblies of mammalian genomes from massively parallel sequence data [J].

Gnerre, Sante ;

MacCallum, Iain ;

Przybylski, Dariusz ;

Ribeiro, Filipe J. ;

Burton, Joshua N. ;

Walker, Bruce J. ;

Sharpe, Ted ;

Hall, Giles ;

Shea, Terrance P. ;

Sykes, Sean ;

Berlin, Aaron M. ;

Aird, Daniel ;

Costello, Maura ;

Daza, Riza ;

Williams, Louise ;

Nicol, Robert ;

Gnirke, Andreas ;

Nusbaum, Chad ;

Lander, Eric S. ;

Jaffe, David B. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (04) :1513-1518

[19] Solution hybrid selection with ultra-long oligonucleotides for massively parallel targeted sequencing [J].

Gnirke, Andreas ;

Melnikov, Alexandre ;

Maguire, Jared ;

Rogov, Peter ;

LeProust, Emily M. ;

Brockman, William ;

Fennell, Timothy ;

Giannoukos, Georgia ;

Fisher, Sheila ;

Russ, Carsten ;

Gabriel, Stacey ;

Jaffe, David B. ;

Lander, Eric S. ;

Nusbaum, Chad .

NATURE BIOTECHNOLOGY, 2009, 27 (02) :182-189

[20] A First-Generation Haplotype Map of Maize [J].

Gore, Michael A. ;

Chia, Jer-Ming ;

Elshire, Robert J. ;

Sun, Qi ;

Ersoz, Elhan S. ;

Hurwitz, Bonnie L. ;

Peiffer, Jason A. ;

McMullen, Michael D. ;

Grills, George S. ;

Ross-Ibarra, Jeffrey ;

Ware, Doreen H. ;

Buckler, Edward S. .

SCIENCE, 2009, 326 (5956) :1115-1117

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