Neurodegeneration augments the ability of bone marrow-derived mesenchymal stem cells to fuse with Purkinje neurons in Niemann-Pick type C mice

被引：60

作者：

Bae, JS

Furuya, S

Shinoda, Y

Endo, S

Schuchman, EH

Hirabayashi, Y

Jin, HK ^{[1
]}

机构：

[1] Kyungpook Natl Univ, Coll Vet Med, Taejon 702701, South Korea

[2] RIKEN, Brain Sci Inst, Neuronal Circuit Mechanisms Res Grp, Wako, Saitama 3510198, Japan

[3] RIKEN, Brain Sci Inst, Lab Learning & Memory, Wako, Saitama 3510198, Japan

[4] CUNY Mt Sinai Sch Med, Dept Human Genet, New York, NY 10029 USA

[5] CUNY Mt Sinai Sch Med, Carl C Icahn Inst Gene Therapy & Mol Med, New York, NY 10029 USA

[6] Kyungpook Natl Univ, Pain & Neural Injury Res Ctr, MRC, Taejon 702701, South Korea

来源：

HUMAN GENE THERAPY | 2005年 / 16卷 / 08期

关键词：

D O I：

10.1089/hum.2005.16.1006

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

After transplantation, adult bone marrow-derived mesenchymal stem cells (BM-MSCs) may undergo trans-differentiation and/or cell fusion in response to new environments. However, the mechanism(s) that govern these cell fate switches remain unknown. Here we demonstrate that the pathology associated with murine Niemann-Pick disease type C (NP-C) cerebellum augments the ability of BM-MSCs to fuse with Purkinje neurons. The results suggest that the degenerative microenvironment of Purkinje neurons in the NP-C cerebellum modulates the cell fate switch of BM-MSCs via cell fusion.

引用

收藏

页码：1006 / 1011

页数：6

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