A highly stereoselective synthesis of the indolo[2,3-a]quinolizine ring system and application to natural product synthesis

被引：28

作者：

Allin, SM ^{[1
]}

Thomas, CI

Allard, JE

Doyle, K

Elsegood, MRJ

机构：

[1] Univ Loughborough, Dept Chem, Loughborough LE11 3TU, Leics, England

[2] OSI Pharmaceut, Oxford OX4 6LT, England

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2005年 / 2005卷 / 19期

关键词：

natural products; heterocycles; lactams; asymmetric synthesis;

D O I：

10.1002/ejoc.200500412

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We present a facile and highly stereoselective approach to the indolo[2,3-alpha]quinolizine ring system from a readily available, non-racemic chiral template. We demonstrate the potential for application of this methodology to natural product synthesis through conversion of the template to some representative indole alkaloids with high enantiomeric purity in both enantiomeric series.

引用

页码：4179 / 4186

页数：8

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