Get to grips: steering local actin dynamics with IQGAPs

被引：119

作者：

Brandt, Dominique T. ^{[1
]}

Grosse, Robert ^{[1
]}

机构：

[1] Heidelberg Univ, Inst Pharmacol, D-69120 Heidelberg, Germany

来源：

EMBO REPORTS | 2007年 / 8卷 / 11期

关键词：

IQGAP; formins; N-WASp; ARP2/3; actin;

D O I：

10.1038/sj.embor.7401089

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

IQGAPs are actin- binding proteins that scaffold numerous interaction partners, transmitting extracellular signals that influence mitogenic, morphological and migratory cell behaviour. However, the precise mechanisms by which IQGAP proteins influence actin dynamics and actin filament structures have been elusive. Now that IQGAP1 has emerged as a potential key regulator of actin-cytoskeletal dynamics by recruiting both the actin related protein ( Arp) 2/ 3 complex and/ or formin- dependent actin polymerizing machineries, we propose that IQGAP1 might coordinate the function of mechanistically different actin nucleators for cooperative localized actin filament production in various cellular processes.

引用

页码：1019 / 1023

页数：5

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