Silica-supported 5-(pyrrolidin-2-yl)tetrazole: development of organocatalytic processes from batch to continuous-flow conditions

被引：64

作者：

Bortolini, Olga ^{[1
]}

Caciolli, Lorenzo ^{[1
]}

Cavazzini, Alberto ^{[2
]}

Costa, Valentina ^{[2
]}

Greco, Roberto ^{[2
]}

Massi, Alessandro ^{[1
]}

Pasti, Luisa ^{[2
]}

机构：

[1] Univ Ferrara, Dipartmento Chim, Chim Organ Lab, I-44121 Ferrara, Italy

[2] Univ Ferrara, Dipartmento Chim, Lab Chim Analit, I-44121 Ferrara, Italy

来源：

GREEN CHEMISTRY | 2012年 / 14卷 / 04期

关键词：

ASYMMETRIC MANNICH; ORGANIC-SYNTHESIS; INCREASED REACTIVITY; CARBONYL-COMPOUNDS; PROLINE; ALDOL; TETRAZOLE; MICHAEL; ROUTE; DERIVATIVES;

D O I：

10.1039/c2gc16673a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

5-(Pyrrolidin-2-yl)tetrazole functionalized silica prepared by photoinduced thiol-ene coupling is packed into a short stainless steel column. The resulting packed-bed microreactor is conveniently heated to perform environmentally benign continuous-flow aldol reactions with good stereoselectivities, complete conversion efficiencies, and long term stability of the packing material.

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页码：992 / 1000

页数：9

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