Malaria parasite transporters as a drug-delivery strategy

被引：33

作者：

Biagini, GA ^{[1
]}

Ward, SA ^{[1
]}

Bray, PG ^{[1
]}

机构：

[1] Univ Liverpool, Liverpool Sch Trop Med, Liverpool L3 5QA, Merseyside, England

来源：

TRENDS IN PARASITOLOGY | 2005年 / 21卷 / 07期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/j.pt.2005.05.013

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

The recent characterization of the choline carrier of the malaria parasite and its role in the selective delivery of novel antimalarial drugs has reignited interest in parasite transporters as a drug-delivery strategy. In this article, we discuss these findings in relation to the wider context of developing a sustainable antimalarial-drug-development portfolio.

引用

页码：299 / 301

页数：3

共 37 条

[1] Plasmodium falciparum likely encodes the principal anion channel on infected human erythrocytes [J].

Alkhalil, A ;

Cohn, JV ;

Wagner, MA ;

Cabrera, JS ;

Rajapandi, T ;

Desai, SA .

BLOOD, 2004, 104 (13) :4279-4286

[2] The membrane potential of the intraerythrocytic malaria parasite Plasmodium falciparum [J].

Allen, RJW ;

Kirk, K .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (12) :11264-11272

[3] Potent inhibitors of Plasmodium phospholipid metabolism with a broad spectrum of in vitro antimalarial activities [J].

Ancelin, ML ;

Calas, M ;

Vidal-Sailhan, V ;

Herbuté, S ;

Ringwald, P ;

Vial, HJ .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2003, 47 (08) :2590-2597

[4] Antimalarial activity of 77 phospholipid polar head analogs:: Close correlation between inhibition of phospholipid metabolism and in vitro Plasmodium falciparum growth [J].

Ancelin, ML ;

Calas, M ;

Bompart, J ;

Cordina, G ;

Martin, D ;

Ben Bari, M ;

Jei, T ;

Druilhe, P ;

Vial, HJ .

BLOOD, 1998, 91 (04) :1426-1437

[5] Characterization of the choline carrier of Plasmodium falciparum:: a route for the selective delivery of novel antimalarial chugs [J].

Biagini, GA ;

Pasini, EM ;

Hughes, R ;

De Koning, HP ;

Vial, HJ ;

O'Neill, PM ;

Ward, SA ;

Bray, PG .

BLOOD, 2004, 104 (10) :3372-3377

[6] Antimalarial chemotherapy: young guns or back to the future? [J].

Biagini, GA ;

O'Neill, PM ;

Nzila, A ;

Ward, SA ;

Bray, PG .

TRENDS IN PARASITOLOGY, 2003, 19 (11) :479-487

[7] Heme binding contributes to antimalarial activity of bis-quaternary ammoniums [J].

Biagini, GA ;

Richier, E ;

Bray, PG ;

Calas, M ;

Vial, H ;

Ward, SA .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2003, 47 (08) :2584-2589

[8] Isolation and functional characterization of the PfNT1 nucleoside transporter gene from Plasmodium falciparum [J].

Carter, NS ;

Ben Mamoun, C ;

Liu, W ;

Silva, EO ;

Landfear, SM ;

Goldberg, DE ;

Ullman, B .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (14) :10683-10691

[9] Anionic channels in malaria-infected human red blood cells [J].

Decherf, G ;

Egée, S ;

Staines, HM ;

Ellory, JC ;

Thomas, SL .

BLOOD CELLS MOLECULES AND DISEASES, 2004, 32 (03) :366-371

[10] A voltage-dependent channel involved in nutrient uptake by red blood cells infected with the malaria parasite [J].

Desai, SA ;

Bezrukov, SM ;

Zimmerberg, J .

NATURE, 2000, 406 (6799) :1001-1005

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