A spatial map of olfactory receptor expression in the Drosophila antenna

被引：947

作者：

Vosshall, LB

Amrein, H

Morozov, PS

Rzhetsky, A

Axel, R ^{[1
]}

机构：

[1] Columbia Univ, Coll Phys & Surg, Howard Hughes Med Inst, Dept Biochem & Mol Biophys, New York, NY 10032 USA

[2] Columbia Univ, Coll Phys & Surg, Columbia Genome Ctr, New York, NY 10032 USA

来源：

CELL | 1999年 / 96卷 / 05期

关键词：

D O I：

10.1016/S0092-8674(00)80582-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Insects provide an attractive system for the study of olfactory sensory perception. We have identified a novel family of seven transmembrane domain proteins, encoded by 100 to 200 genes, that is likely to represent the family of Drosophila odorant receptors. Members of this gene family are expressed in topographically defined subpopulations of olfactory sensory neurons in either the antenna or the maxillary palp. Sensory neurons express different complements of receptor genes, such that individual neurons are functionally distinct. The isolation of candidate odorant receptor genes along with a genetic analysis of olfactory-driven behavior in insects may ultimately afford a system to understand the mechanistic link between odor recognition and behavior.

引用

页码：725 / 736

页数：12

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