Amyloid beta peptide processing, insulin degrading enzyme, and butyrylcholinesterase

被引：9

作者：

Balasubramanian, AS ^{[1
]}

机构：

[1] Bharathiar Univ, Dept Biotechnol, Coimbatore 641046, Tamil Nadu, India

来源：

NEUROCHEMICAL RESEARCH | 2001年 / 26卷 / 04期

关键词：

Alzheimers disease; amyloid peptide; insulin degrading enzyme; butyrylcholinesterase;

D O I：

10.1023/A:1010967602362

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Amyloid beta peptide implicated in Alzheimers disease is cleaved by insulin degrading enzyme (IDE). Abnormal cholinesterases similar to butyrylcholinesterase (BChE) are found in Alzheimer brain. The similarities between IDE and BChE (which is known to have an arylacylamidase and a metallocarboxypeptidase-like activity) such as their zinc metalloenzyme nature, their localization in glia and their ability to bind amyloid peptide in Alzheimers disease raise interesting questions.

引用

页码：453 / 456

页数：4

共 28 条

[11] Butyrylcholinesterase in the life cycle of amyloid plaques
Guillozet, AL
Smiley, JF
Mash, DC
Mesulam, MM
[J]. ANNALS OF NEUROLOGY, 1997, 42 (06) : 909 - 918
[12] IDENTIFICATION OF HUMAN PLASMA CHOLINESTERASE VARIANTS USING MOLECULAR BIOLOGICAL TECHNIQUES
JENSEN, FS
SCHWARTZ, M
VIBYMOGENSEN, J
[J]. ACTA ANAESTHESIOLOGICA SCANDINAVICA, 1995, 39 (02) : 142 - 149
[13] Amyloidogenic determinant as a substrate recognition motif of insulin-degrading enzyme
Kurochkin, IV
[J]. FEBS LETTERS, 1998, 427 (02) : 153 - 156
[14] The secretion of amyloid β-peptides is inhibited in the tacrine-treated human neuroblastoma cells
Lahiri, DK
Farlow, MR
Sambamurti, K
[J]. MOLECULAR BRAIN RESEARCH, 1998, 62 (02): : 131 - 140
[15] Association of butyrylcholinesterase K variant with cholinesterase-positive neuritic plaques in the temporal cortex in late-onset Alzheimer's disease
Lehman, DJ
Nagy, Z
Litchfield, S
Borja, MC
Smith, AD
[J]. HUMAN GENETICS, 2000, 106 (04) : 447 - 452
[16] Synergy between the genes for butyrylcholinesterase K variant and apolipoprotein E4 in late-onset confirmed Alzheimer's disease
Lehmann, DJ
Johnston, C
Smith, AD
[J]. HUMAN MOLECULAR GENETICS, 1997, 6 (11) : 1933 - 1936
[17] Butyrylcholinesterase K variant is genetically associated with late onset Alzheimer's disease in Northern Ireland
McIlroy, SP
Crawford, VLS
Dynan, KB
McGleenon, BM
Vahidassr, MD
Lawson, JT
Passmore, AP
[J]. JOURNAL OF MEDICAL GENETICS, 2000, 37 (03) : 182 - 185
[18] Insulin-degrading enzyme regulates extracellular levels of amyloid β-protein by degradation
Qiu, WQ
Walsh, DM
Ye, Z
Vekrellis, K
Zhang, JM
Podlisny, MB
Rosner, MR
Safavi, A
Hersh, LB
Selkoe, DJ
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (49) : 32730 - 32738
[19] THE PEPTIDASE ACTIVITY OF HUMAN SERUM BUTYRYLCHOLINESTERASE - STUDIES USING MONOCLONAL-ANTIBODIES AND CHARACTERIZATION OF THE PEPTIDASE
RAO, RV
BALASUBRAMANIAN, AS
[J]. JOURNAL OF PROTEIN CHEMISTRY, 1993, 12 (01): : 103 - 110
[20] Neuroscience - Alzheimer's disease: Genotypes, phenotype, and treatments
Selkoe, DJ
[J]. SCIENCE, 1997, 275 (5300) : 630 - 631

← 1 2 3 →