The basal ganglia and cognitive pattern generators

被引:239
作者
Graybiel, AM
机构
[1] Dept. of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Bldg. E25, Cambridge
关键词
D O I
10.1093/schbul/23.3.459
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
This article introduces the notion of cognitive pattern generators and suggests, by analogy with the central pattern generators of the motor system, that these pattern generators operate to organize neural activity underlying aspects of action-oriented cognition. It is further proposed that the basal ganglia are involved in the control of cognitive as well as motor pattern generators. Disorders of the basal ganglia may thereby contribute to neural circuit dysfunctions that are expressed as positive and negative symptoms of schizophrenia.
引用
收藏
页码:459 / 469
页数:11
相关论文
共 92 条
[61]  
Mishkin M., 1984, Neuropsychology of memory, Guilford Press, New York, P287
[62]   BRAIN-STIMULATION REWARD AFTER 25 YEARS [J].
MOGENSON, GJ ;
PHILLIPS, AG .
CANADIAN JOURNAL OF PSYCHOLOGY-REVUE CANADIENNE DE PSYCHOLOGIE, 1978, 32 (02) :54-57
[63]   FUNCTIONAL-ANATOMY OF THE BASAL GANGLIA .1. THE CORTICO-BASAL GANGLIA-THALAMO-CORTICAL LOOP [J].
PARENT, A ;
HAZRATI, LN .
BRAIN RESEARCH REVIEWS, 1995, 20 (01) :91-127
[64]   FUNCTIONAL-ANATOMY OF THE BASAL GANGLIA .2. THE PLACE OF SUBTHALAMIC NUCLEUS AND EXTERNAL PALLIDUM IN BASAL GANGLIA CIRCUITRY [J].
PARENT, A ;
HAZRATI, LN .
BRAIN RESEARCH REVIEWS, 1995, 20 (01) :128-154
[65]  
PARTHASARATHY HB, 1992, J NEUROSCI, V12, P4468
[66]   THE CASE FOR FRONTOSTRIATAL DYSFUNCTION IN SCHIZOPHRENIA [J].
ROBBINS, TW .
SCHIZOPHRENIA BULLETIN, 1990, 16 (03) :391-402
[67]   Reduced striatal spine size in schizophrenia: A postmortem ultrastructural study [J].
Roberts, RC ;
Conley, R ;
Kung, LL ;
Peretti, FJ ;
Chute, DJ .
NEUROREPORT, 1996, 7 (06) :1214-1218
[68]   ENDURING CHANGES IN BRAIN AND BEHAVIOR PRODUCED BY CHRONIC AMPHETAMINE ADMINISTRATION - A REVIEW AND EVALUATION OF ANIMAL-MODELS OF AMPHETAMINE PSYCHOSIS [J].
ROBINSON, TE ;
BECKER, JB .
BRAIN RESEARCH REVIEWS, 1986, 11 (02) :157-198
[69]  
ROLAND PE, 1987, CIBA F SYMP, V132, P251
[70]  
Rossignol Serge, 1994, Current Opinion in Neurobiology, V4, P894, DOI 10.1016/0959-4388(94)90139-2