Self-renewal of hematopoietic and leukemic stem cells:: a central role for the Polycomb-group gene Bmi-1

被引：79

作者：

Raaphorst, FM ^{[1
]}

机构：

[1] Free Univ Amsterdam, Ctr Med, Dept Pathol, NL-1081 HV Amsterdam, Netherlands

来源：

TRENDS IN IMMUNOLOGY | 2003年 / 24卷 / 10期

关键词：

D O I：

10.1016/S1471-4906(03)00241-2

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Self-renewal of hematopoietic stem cells is vital for the sustained daily production of blood cells. Two recent studies have shown that the Polycomb-group gene Bmi-1 is indispensable for regulation of self-renewal by normal and leukemic stem cells. This identifies Polycomb-group genes as potential targets for therapeutic intervention in leukemia, and possibly other forms of cancer.

引用

页码：522 / 524

页数：3

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