Liver tumors: Comparison of MR imaging with Gd-EOB-DTPA and Gd-DTPA

被引:374
作者
Vogl, TJ
Kummel, S
Hammerstingl, R
Schellenbeck, M
Schumacher, G
Balzer, T
Schwarz, W
Muller, PK
Bechstein, WO
Mack, MG
Sollner, O
Felix, R
机构
[1] HUMBOLDT UNIV BERLIN,RUDOLF VIRCHOW HOSP,DEPT SURG,D-13353 BERLIN,GERMANY
[2] SCHERING AG,W-1000 BERLIN,GERMANY
关键词
gadolinium; liver; MR; magnetic resonance (MR); contrast agents; contrast enhancement;
D O I
10.1148/radiology.200.1.8657946
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
PURPOSE: To compare the usefulness of gadolinium ethoxybenzyl diethylenetriaminepentaacetic acid (Gd-EOB-DTPA) and gadolinium diethylenetriaminepentaacetic acid (Gd-DTPA) in the diagnosis of focal liver lesions. MATERIALS AND METHODS: Thirty-one patients with focal liver lesions underwent T2- and T1-weighted spin-echo magnetic resonance (MR) imaging and fast low-angle shot two-dimensional MR imaging before, during, and after intravenous administration of three different doses of Gd-EOB-DTPA (12.5, 25, and 50 mu mol per kilogram body weight). Gd-DTPA-enhanced imaging (dose, 0.1 mmol per kilogram body weight) was performed in the same patients within 1 week of Gd-EOB-DTPA imaging. RESULTS: During the perfusion phase (the 3 minutes after injection of contrast material), the dynamic enhancement characteristics seen after injection of 25 and 50 mu mol of Gd-EOB-DTPA were similar to those seen with Gd-DTPA. At the lowest dose of Gd-EOB-DTPA (12.5 mu mol), the dynamic enhancement characteristics were not comparable to those seen with Gd-DTPA. During the hepatobiliary phase (1.5 minutes to 4 hours after injection), Gd-EOB-DTPA-enhanced images yielded a dose-independent, statistically significant improvement in the detection rate of additional metastases, hepatocellular carcinomas, and hemangiomas compared with unenhanced and Gd-DTPA-enhanced images (P < .95). CONCLUSION: Gd-EOB-DTPA-enhanced MR imaging enables improved detection of hepatic lesions over Gd-DTPA-enhanced MR imaging while providing comparable differential diagnostic information.
引用
收藏
页码:59 / 67
页数:9
相关论文
共 17 条
  • [1] HEPATIC MR IMAGING WITH MN-DPDP - SAFETY, IMAGE QUALITY, AND SENSITIVITY
    BERNARDINO, ME
    YOUNG, SW
    LEE, JKT
    WEINREB, JC
    [J]. RADIOLOGY, 1992, 183 (01) : 53 - 58
  • [2] COMPARISON OF GD-EOB-DTPA AND GD-DTPA FOR CONTRAST-ENHANCED MR-IMAGING OF LIVER-TUMORS
    CLEMENT, O
    MUHLER, A
    VEXLER, VS
    KUWATSURU, R
    BERTHEZENE, Y
    ROSENAU, W
    BRASCH, RC
    [J]. JMRI-JOURNAL OF MAGNETIC RESONANCE IMAGING, 1993, 3 (01): : 71 - 77
  • [3] CLEMENT O, 1992, INVEST RADIOL, V27, P612
  • [4] FOCAL LIVER-LESIONS - CHARACTERIZATION WITH NONENHANCED AND DYNAMIC CONTRAST MATERIAL-ENHANCED MR-IMAGING
    HAMM, B
    THOENI, RF
    GOULD, RG
    BERNARDINO, ME
    LUNING, M
    SAINI, S
    MAHFOUZ, AE
    TAUPITZ, M
    WOLF, KJ
    [J]. RADIOLOGY, 1994, 190 (02) : 417 - 423
  • [5] FOCAL LIVER-LESIONS - MR IMAGING WITH MN-DPDP - INITIAL CLINICAL-RESULTS IN 40 PATIENTS
    HAMM, B
    VOGL, TJ
    BRANDING, G
    SCHNELL, B
    TAUPITZ, M
    WOLF, KJ
    LISSNER, J
    [J]. RADIOLOGY, 1992, 182 (01) : 167 - 174
  • [6] PHASE-I CLINICAL-EVALUATION OF GD-EOB-DTPA AS A HEPATOBILIARY MR CONTRAST AGENT - SAFETY, PHARMACOKINETICS, AND MR-IMAGING
    HAMM, B
    STAKS, T
    MUHLER, A
    BOLLOW, M
    TAUPITZ, M
    FRENZEL, T
    WOLF, KJ
    WEINMANN, HJ
    LANGE, L
    [J]. RADIOLOGY, 1995, 195 (03) : 785 - 792
  • [7] HYPERVASCULAR LIVER-LESIONS - DIFFERENTIATION OF FOCAL NODULAR HYPERPLASIA FROM MALIGNANT-TUMORS WITH DYNAMIC GADOLINIUM-ENHANCED MR IMAGING
    MAHFOUZ, AE
    HAMM, B
    TAUPITZ, M
    WOLF, KJ
    [J]. RADIOLOGY, 1993, 186 (01) : 133 - 138
  • [8] COMPARISON BETWEEN GD-DTPA, GD-EOB-DTPA, AND MN-DPDP IN INDUCED HCC IN RATS - A CORRELATION STUDY OF MR-IMAGING, MICROANGIOGRAPHY, AND HISTOLOGY
    MARCHAL, G
    ZHANG, X
    NI, Y
    VANHECKE, P
    YU, J
    BAERT, AL
    [J]. MAGNETIC RESONANCE IMAGING, 1993, 11 (05) : 665 - 674
  • [9] ELIMINATION OF GADOLINIUM-ETHOXYBENZYL-DTPA IN A RAT MODEL OF SEVERELY IMPAIRED LIVER AND KIDNEY EXCRETORY FUNCTION - AN EXPERIMENTAL-STUDY IN RATS
    MUHLER, A
    HEINZELMANN, I
    WEINMANN, HJ
    [J]. INVESTIGATIVE RADIOLOGY, 1994, 29 (02) : 213 - 216
  • [10] MUHLER A, 1993, INVEST RADIOL, V28, P26