Leishmaniasis: complexity at the host-pathogen interface

被引：654

作者：

Kaye, Paul ^{[1
,2
]}

Scott, Phillip ^{[3
]}

机构：

[1] Univ York, Dept Biol, Ctr Immunol & Infect, York YO10 5YW, N Yorkshire, England

[2] Univ York, Hull York Med Sch, York YO10 5YW, N Yorkshire, England

[3] Univ Penn, Sch Vet Med, Dept Pathobiol, Penn Inst Immunol, Philadelphia, PA 19104 USA

来源：

NATURE REVIEWS MICROBIOLOGY | 2011年 / 9卷 / 08期

基金：

美国国家卫生研究院; 英国惠康基金; 英国医学研究理事会;

关键词：

PROTOZOAN PARASITE LEISHMANIA; CD8(+) T-CELLS; EXPERIMENTAL VISCERAL LEISHMANIASIS; NEUTROPHIL EXTRACELLULAR TRAPS; PROTEIN-TYROSINE PHOSPHATASES; SAND FLY VECTOR; DENDRITIC CELLS; MAJOR INFECTION; CUTANEOUS LEISHMANIASIS; DONOVANI PROMASTIGOTES;

D O I：

10.1038/nrmicro2608

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Leishmania is a genus of protozoan parasites that are transmitted by the bite of phlebotomine sandflies and give rise to a range of diseases (collectively known as leishmaniases) that affect over 150 million people worldwide. Cellular immune mechanisms have a major role in the control of infections with all Leishmania spp. However, as discussed in this Review, recent evidence suggests that each host-pathogen combination evokes different solutions to the problems of parasite establishment, survival and persistence. Understanding the extent of this diversity will be increasingly important in ensuring the development of broadly applicable vaccines, drugs and immunotherapeutic interventions.

引用

页码：604 / 615

页数：12

共 120 条

[61] Leishmaniasis Vaccine: Where are We Today? [J].

Kedzierski, Lukasz .

JOURNAL OF GLOBAL INFECTIOUS DISEASES, 2010, 2 (02) :177-185

[62] Biogenesis of Leishmania major-harboring vacuoles in murine dendritic cells [J].

Körner, U ;

Fuss, V ;

Steigerwald, J ;

Moll, H .

INFECTION AND IMMUNITY, 2006, 74 (02) :1305-1312

[63] IL-17 Promotes Progression of Cutaneous Leishmaniasis in Susceptible Mice [J].

Kostka, Susanna Lopez ;

Dinges, Stephanie ;

Griewank, Klaus ;

Iwakura, Yoichiro ;

Udey, Mark C. ;

von Stebut, Esther .

JOURNAL OF IMMUNOLOGY, 2009, 182 (05) :3039-3046

[64] Neutrophil granulocytes -: Trojan horses for Leishmania major and other intracellular microbes? [J].

Laskay, T ;

van Zandbergen, G ;

Solbach, W .

TRENDS IN MICROBIOLOGY, 2003, 11 (05) :210-214

[65] Monocyte-derived dendritic cells formed at the infection site control the induction of protective T helper 1 responses against Leishmania [J].

Leon, Beatriz ;

Lopez-Bravo, Maria ;

Ardavin, Carlos .

IMMUNITY, 2007, 26 (04) :519-531

[66] Real-time imaging of Leishmania mexicana-infected early phagosomes: a study using primary macrophages generated from green fluorescent protein-Rab5 transgenic mice [J].

Lippuner, Christoph ;

Paape, Daniel ;

Paterou, Athina ;

Brand, Janko ;

Richardson, Melville ;

Smith, Andrew J. ;

Hoffmann, Kirstin ;

Brinkmann, Volker ;

Blackburn, Clare ;

Aebischer, Toni .

FASEB JOURNAL, 2009, 23 (02) :483-491

[67] Oral pentoxifylline combined with pentavalent antimony: A randomized trial for mucosal leishmaniasis [J].

Machado, Paulo R. L. ;

Lessa, Helio ;

Lessa, Marcus ;

Guimaraes, Luiz H. ;

Bang, Heejung ;

Ho, John L. ;

Carvalho, Edgar M. .

CLINICAL INFECTIOUS DISEASES, 2007, 44 (06) :788-793

[68] Posttranscriptional regulation of Il10 gene expression allows natural killer cells to express immunoregulatory function [J].

Maroof, Asher ;

Beattie, Lynette ;

Zubairi, Soombul ;

Svensson, Mattias ;

Stager, Simona ;

Kaye, Paul M. .

IMMUNITY, 2008, 29 (02) :295-305

[69] Dendritic Cells Matured by Inflammation Induce CD86-Dependent Priming of Naive CD8+ T Cells in the Absence of Their Cognate Peptide Antigen [J].

Maroof, Asher ;

Beattie, Lynette ;

Kirby, Alun ;

Coles, Mark ;

Kaye, Paul M. .

JOURNAL OF IMMUNOLOGY, 2009, 183 (11) :7095-7103

[70] CD40 Signaling in CD8+CD40+ T Cells Turns On Contra-T Regulatory Cell Functions [J].

Martin, Sunil ;

Pahari, Sushmita ;

Sudan, Raki ;

Saha, Bhaskar .

JOURNAL OF IMMUNOLOGY, 2010, 184 (10) :5510-5518

← 2 3 4 5 6 7 8 9 10 11 →