Synaptic mechanisms of associative memory in the amygdala

被引：255

作者：

Maren, S ^{[1
]}

机构：

[1] Univ Michigan, Dept Psychol, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Neurosci Program, Ann Arbor, MI 48109 USA

来源：

NEURON | 2005年 / 47卷 / 06期

关键词：

D O I：

10.1016/j.neuron.2005.08.009

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Do associative learning and synaptic long-term potentiation (LTP) depend on the same cellular mechanisms? Recent work in the amygdala reveals that LTP and Pavlovian fear conditioning induce similar changes in postsynaptic AMPA-type glutamate receptors and that occluding these changes by viral-mediated overexpression of a dominant-negative GluR1 construct attenuates both LTP and fear memory in rats. Novel forms of presynaptic plasticity in the lateral nucleus may also contribute to fear memory formation, bolstering the connection between synaptic plasticity mechanisms and associative learning and memory.

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收藏

页码：783 / 786

页数：4

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