The BEAUTIFUL study:: Randomized trial of ivabradine in patients with stable coronary artery disease and left ventricular systolic dysfunction baseline characteristics of the study population

被引：43

作者：

Fox, Kim ^{[1
]}

Recena, J. Balaguer ^{[1
]}

Garcia-Aranda, V. Lopez ^{[1
]}

Valderrama, J. Caparros ^{[1
]}

Alonso, L. F. Iglesias ^{[1
]}

Calvar, A. San Roman ^{[1
]}

Aviles, F. Fernandez ^{[1
]}

Villa, F. Perez ^{[1
]}

Cortada, J. Bruguera ^{[1
]}

Alvarez, R. Fernandez ^{[1
]}

Peiro, F. Noriega ^{[1
]}

Iglesias, F. Calvo ^{[1
]}

Toral, B. Sevilla ^{[1
]}

Bescos, L. Lopez ^{[1
]}

De Burgos, F. Garcia ^{[1
]}

Casado, R. Sola ^{[1
]}

Galve, E. ^{[1
]}

Garcia, G. Casares ^{[1
]}

Dellborg, M. ^{[1
]}

Herlitz, J. ^{[1
]}

Ullman, B. ^{[1
]}

Blomgren, J. ^{[1
]}

Bandh, S. ^{[1
]}

Oehlin, H. ^{[1
]}

Dubach, P. ^{[1
]}

Gallino, A. ^{[1
]}

Hess, O. ^{[1
]}

Moccetti, T. ^{[1
]}

Eeckhout, E. ^{[1
]}

Vontobel, H. ^{[1
]}

Delabays, A. ^{[1
]}

Erol, K. ^{[1
]}

Kozan, O. ^{[1
]}

Mutlu, B. ^{[1
]}

Ergene, O. ^{[1
]}

Acarturk, E. ^{[1
]}

Yilmaz, H. ^{[1
]}

Ural, D. ^{[1
]}

Parkhomenko, O. ^{[1
]}

Polyvoda, S. ^{[1
]}

Dyadyk, A. ^{[1
]}

Vatutin, M. ^{[1
]}

Karpenko, O. ^{[1
]}

Kubyshkin, V. ^{[1
]}

Rudenko, L. ^{[1
]}

Putintsev, V. ^{[1
]}

Krayz, I. ^{[1
]}

Kovalsky, I. ^{[1
]}

Rudyk, Y. ^{[1
]}

Yurlov, V. ^{[1
]}

机构：

[1] Royal Brompton Hosp, London SW3 6NP, England

来源：

CARDIOLOGY | 2008年 / 110卷 / 04期

关键词：

coronary artery disease; heart rate; ivabradine; left ventricular dysfunction; mortality;

D O I：

10.1159/000112412

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objectives: Ivabradine is a selective heart rate-lowering agent that acts by inhibiting the pacemaker current I-f in sinoatrial node cells. Patients with coronary artery disease and left ventricular dysfunction are at high risk of death and cardiac events, and the BEAUTIFUL study was designed to evaluate the effects of ivabradine on outcome in such patients receiving optimal medical therapy. This report describes the study population at baseline. Methods: BEAUTIFUL is an international, multicentre, randomized, double-blind trial to compare ivabradine with placebo in reducing mortality and cardiovascular events in patients with stable coronary artery disease and left ventricular systolic dysfunction (ejection fraction < 40%). Results: A total of 10,917 patients were randomized. At baseline, their mean age was 65 years, 83% were male, 98% Caucasian, 88% had previous myocardial infarction, 37% had diabetes, and 40% had metabolic syndrome. Mean ejection fraction was 32% and resting heart rate was 71.6 bpm. Concomitant medications included beta-blockers (87%), renin-angiotensin system agents (89%), antithrombotic agents (94%), and lipid-lowering agents (76%). Conclusions: Main results from BEAUTIFUL are expected in 2008, and should show whether ivabradine, on top of optimal medical treatment, reduces mortality and cardiovascular events in this population of high-risk patients. Copyright (c) 2007 S. Karger AG, Basel.

引用

页码：271 / 282

页数：12

共 69 条

[11] The relationships of left ventricular ejection fraction, end-systolic volume index and infarct size to six-month mortality after hospital discharge following myocardial infarction treated by thrombolysis
Burns, RJ
Gibbons, RJ
Yi, QL
Roberts, RS
Miller, TD
Schaer, GL
Anderson, JL
Yusuf, S
[J]. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2002, 39 (01) : 30 - 36
[12] Tolerability to β-blocker therapy among heart failure patients in clinical practice
Butler, J
Khadim, G
Belue, R
Chomsky, D
Dittus, RS
Griffin, M
Wilson, JR
[J]. JOURNAL OF CARDIAC FAILURE, 2003, 9 (03) : 203 - 209
[13] Electrophysiological Effects of a Single Intravenous Administration of Ivabradine (S 16257) in Adult Patients with Normal Baseline Electrophysiology
A. John Camm
Chu-Pak Lau
[J]. Drugs in R & D, 2003, 4 (2) : 83 - 89
[14] Executive summary of the Third Report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III)
Cleeman, JI
Grundy, SM
Becker, D
Clark, LT
Cooper, RS
Denke, MA
Howard, WJ
Hunninghake, DB
Illingworth, DR
Luepker, RV
McBride, P
McKenney, JM
Pasternak, RC
Stone, NJ
Van Horn, L
Brewer, HB
Ernst, ND
Gordon, D
Levy, D
Rifkind, B
Rossouw, JE
Savage, P
Haffner, SM
Orloff, DG
Proschan, MA
Schwartz, JS
Sempos, CT
Shero, ST
Murray, EZ
[J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2001, 285 (19): : 2486 - 2497
[15] A description of the clinical characteristics at baseline of patients recruited into the Carvedilol or Metoprolol European Trial (COMET)
Cleland, JGF
Goode, K
Erhardt, L
Remme, WJ
Charlesworth, A
Poole-Wilson, PA
Di Lenarda, A
Hanrath, P
Komajda, M
Metra, M
Swedberg, K
Trop-Pedersen, C
[J]. CARDIOVASCULAR DRUGS AND THERAPY, 2004, 18 (02) : 139 - 152
[16] Hospitalization of patients with heart failure - A population-based study
Cowie, MR
Fox, KF
Wood, DA
Metcalfe, C
Thompson, SG
Coats, AJS
Poole-Wilson, PA
Sutton, GC
[J]. EUROPEAN HEART JOURNAL, 2002, 23 (11) : 877 - 885
[17] The association of left ventricular ejection fraction, mortality, and cause of death in stable outpatients with heart failure
Curtis, JP
Sokol, SI
Wang, YF
Rathore, SS
Ko, DT
Jadbabaie, F
Portnay, EL
Marshalko, SJ
Radford, MJ
Krumholz, HM
[J]. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2003, 42 (04) : 736 - 742
[18] Predicting prognosis in stable angina - results from the Euro heart survey of stable angina: prospective observational study
Daly, CA
De Stavola, B
Fox, KM
[J]. BMJ-BRITISH MEDICAL JOURNAL, 2006, 332 (7536): : 262 - 265
[19] The initial management of stable angina in Europe, from the Euro Heart Survey - A description of pharmacological management and revascularization strategies initiated within the first month of presentation to a cardiologist in the Euro Heart Survey of Stable Angina
Daly, CA
Clemens, F
Sendon, JLL
Tavazzi, L
Boersma, E
Danchin, N
Delahaye, F
Gitt, A
Julian, D
Mulcahy, D
Ruzyllo, W
Thygesen, K
Verheugt, F
Fox, KM
[J]. EUROPEAN HEART JOURNAL, 2005, 26 (10) : 1011 - 1022
[20] Long-term prognostic value of resting heart rate in patients with suspected or proven coronary artery disease
Diaz, A
Bourassa, MG
Guertin, MC
Tardif, JC
[J]. EUROPEAN HEART JOURNAL, 2005, 26 (10) : 967 - 974

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