Dde-protected PNA monomers, orthogonal to Fmoc, for the synthesis of PNA-peptide conjugates

被引：30

作者：

Bialy, L ^{[1
]}

Díaz-Mochón, JJ ^{[1
]}

Specker, E ^{[1
]}

Keinicke, L ^{[1
]}

Bradley, M ^{[1
]}

机构：

[1] Univ Edinburgh, Sch Chem, Edinburgh EH9 3JJ, Midlothian, Scotland

来源：

TETRAHEDRON | 2005年 / 61卷 / 34期

基金：

英国生物技术与生命科学研究理事会;

关键词：

PNA; Dde; Fmoc; orthogonality; conjugate; peptide;

D O I：

10.1016/j.tet.2005.06.003

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Peptide nucleic acids have become, arguably, one of the most interesting of DNA mimics. Herein the efficient solution phase synthesis of four novel 1-(4,4-dimethyl-2,6-dioxacyclohexylidene)ethyl/4-methoxytrityl (Dde/Mmt) protected PNA monomers is reported which were then used to synthesise PNA-peptide conjugates through a mild Dde deprotection strategy, which was fully orthogonal to Fmoc chemistry, allowing at will Fmoc peptide and Dde-PNA synthesis. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：8295 / 8305

页数：11

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