FTICR mass spectrometry for qualitative and quantitative bioanalyses

被引：31

作者：

Page, JS

Masselon, CD

Smith, RD

机构：

[1] Pacific NW Natl Lab, Div Biol Sci, Richland, WA 99352 USA

[2] Pacific NW Natl Lab, Environm Mol Sci Lab, Richland, WA 99352 USA

来源：

CURRENT OPINION IN BIOTECHNOLOGY | 2004年 / 15卷 / 01期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/j.copbio.2004.01.002

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Fourier transform ion cyclotron resonance mass spectrometry (FTICR-MS) is playing an increasing role in the characterization of cellular systems owing to its capabilities for providing higher confidence of identification, increased dynamic range and sensitivity unmatched by other MS platforms. Particularly in proteomics, where global and quantitative approaches are essential, the attributes of FTICR-MS are poised to make significant contributions. Recent advances in the field that have particular importance for proteomic applications include the use of high-performance micro-capillary column separation techniques coupled to FTICR, as well as methods that improve protein identification, sensitivity, dynamic range and throughput.

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页码：3 / 11

页数：9

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