Genetic and functional relationships between MHC and NK receptor genes

被引：253

作者：

Trowsdale, J ^{[1
]}

机构：

[1] Univ Cambridge, Dept Pathol, Div Immunol, Cambridge CB2 1QP, England

来源：

IMMUNITY | 2001年 / 15卷 / 03期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/S1074-7613(01)00197-2

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

HLA class I and NK receptors are encoded within dense clusters of immune loci. The MHC, at 6p21.3, and the complex containing the KIR loci, at 19q13.4, both feature variation in the number of genes, as well as sequence polymorphism. In addition to T cell receptors, several variable class I-related molecules interact with polymorphic NK receptors. Some of the lectin-related NK receptor genes, at 12p13.1, also have ligands belonging to the extended class I family. The expanding clusters of class I-related sequences and. their receptors, some of which evolved recently, reveal further complexity in immune recognition of disease.

引用

收藏

页码：363 / 374

页数：12

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