Genetic and functional relationships between MHC and NK receptor genes

被引：253

作者：

Trowsdale, J ^{[1
]}

机构：

[1] Univ Cambridge, Dept Pathol, Div Immunol, Cambridge CB2 1QP, England

来源：

IMMUNITY | 2001年 / 15卷 / 03期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/S1074-7613(01)00197-2

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

HLA class I and NK receptors are encoded within dense clusters of immune loci. The MHC, at 6p21.3, and the complex containing the KIR loci, at 19q13.4, both feature variation in the number of genes, as well as sequence polymorphism. In addition to T cell receptors, several variable class I-related molecules interact with polymorphic NK receptors. Some of the lectin-related NK receptor genes, at 12p13.1, also have ligands belonging to the extended class I family. The expanding clusters of class I-related sequences and. their receptors, some of which evolved recently, reveal further complexity in immune recognition of disease.

引用

收藏

页码：363 / 374

页数：12

相关论文

共 88 条

[41]

Gruen JR, 1997, BLOOD, V90, P4252

[42] The carcinoembryonic antigen (CEA) family:: structures, suggested functions and expression in normal and malignant tissues [J].

Hammarström, S .

SEMINARS IN CANCER BIOLOGY, 1999, 9 (02) :67-81

[43] Immunogenetics - Defence by diversity [J].

Hill, AVS .

NATURE, 1999, 398 (6729) :668-669

[44] Large-scale sequence comparisons reveal unusually high levels of variation in the HLA-DQB1 locus in the class II region of the human MHC [J].

Horton, R ;

Niblett, D ;

Milne, S ;

Palmer, S ;

Tubby, B ;

Trowsdale, J ;

Beck, S .

JOURNAL OF MOLECULAR BIOLOGY, 1998, 282 (01) :71-97

[45] Role of immunoreceptor tyrosine-based activation motif in signal transduction from antigen and Fc receptors [J].

Isakov, N .

ADVANCES IN IMMUNOLOGY, VOL 69, 1998, 69 :183-247

[46] High resolution analysis of haplotype diversity and meiotic crossover in the human TAP2 recombination hotspot [J].

Jeffreys, AJ ;

Ritchie, A ;

Neumann, R .

HUMAN MOLECULAR GENETICS, 2000, 9 (05) :725-733

[47] How to recognize a foreign submarine [J].

Karre, K .

IMMUNOLOGICAL REVIEWS, 1997, 155 :5-9

[48] The chicken B locus is a minimal essential major histocompatibility complex [J].

Kaufman, J ;

Milne, S ;

Göbel, TWF ;

Walker, BA ;

Jacob, JP ;

Auffray, C ;

Zoorob, R ;

Beck, S .

NATURE, 1999, 401 (6756) :923-925

[49] Rapid evolution of NK cell receptor systems demonstrated by comparison of chimpanzees and humans [J].

Khakoo, SI ;

Rajalingam, R ;

Shum, BP ;

Weidenbach, K ;

Flodin, L ;

Muir, DG ;

Canavez, F ;

Cooper, SL ;

Valiante, NM ;

Lanier, LL ;

Parham, P .

IMMUNITY, 2000, 12 (06) :687-698

[50] Recognition of trophoblast HLA class I molecules by decidual NK cell receptors - A review [J].

King, A ;

Hiby, SE ;

Gardner, L ;

Joseph, S ;

Bowen, JM ;

Verma, S ;

Burrows, TD ;

Loke, YW .

PLACENTA, 2000, 21 :S81-S85

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