Hypothalamic paraventricular injections of ghrelin: effect on feeding and c-Fos immunoreactivity

被引：90

作者：

Olszewski, PK

Grace, MK

Billington, CJ

Levine, AS

机构：

[1] Vet Affairs Med Ctr, Minneapolis, MN 55417 USA

[2] Univ Minnesota, Dept Med, Minneapolis, MN 55455 USA

[3] Univ Minnesota, Dept Food Sci & Nutr, Minneapolis, MN 55455 USA

[4] Coll Vet Med, Minneapolis, MN 55455 USA

来源：

PEPTIDES | 2003年 / 24卷 / 06期

关键词：

food intakes; ghrelin; immunohistochemistry; c-Fos; brain stem; amygdala; hypothalamus; injection;

D O I：

10.1016/S0196-9781(03)00159-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The paraventricular hypothalamic nucleus (PVN) appears to integrate orexigenic properties of a novel peptide, ghrelin. Thus, we examined central mechanisms underlying feeding generated by intra-PVN ghrelin. We established that 0.03 nmol of PVN-injected ghrelin was the lowest dose increasing food consumption and it induced c-Fos immunoreactivity (a marker of neuronal activation) in the PVN itself, as well as in other feeding-related brain areas, including the hypothalamic arcuate and dorsomedial nuclei, central nucleus of the amygdala, and nucleus of the solitary tract. We conclude that the PVN, as part of larger central circuitry, mediates orexigenic properties of ghrelin. (C) 2003 Elsevier Inc. All rights reserved.

引用

页码：919 / 923

页数：5