Cbln1 and its family proteins in synapse formation and maintenance

被引：54

作者：

Yuzaki, Michisuke ^{[1
]}

机构：

[1] Keio Univ, Dept Neurophysiol, Sch Med, Shinjuku Ku, Tokyo 1608582, Japan

来源：

CURRENT OPINION IN NEUROBIOLOGY | 2011年 / 21卷 / 02期

基金：

日本科学技术振兴机构;

关键词：

DELTA-2; GLUTAMATE-RECEPTOR; CELL-ADHESION; D-SERINE; DISTINCT EXPRESSION; NMDA RECEPTORS; MESSENGER-RNAS; EPHB RECEPTORS; CEREBELLUM; NEUREXIN; DIFFERENTIATION;

D O I：

10.1016/j.conb.2011.01.010

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Cbln1 is a newly identified synaptic organizer belonging to the C1q family. Unlike other synaptic organizers, a deficiency in Cbln1 is sufficient to cause a severe reduction in the number of synapses between cerebellar Purkinje cells and parallel fibers (PFs). Furthermore, Cbln1 can rapidly induce synaptogenesis and is necessary for maintaining normal synapses in the mature cerebellum in vivo. Cbln1 was recently identified as the missing ligand for the orphan glutamate receptor delta 2 (GluD2), which is expressed in Purkinje cells. Furthermore, Cbln1 released from PFs binds to neurexin (NRX) expressed on the presynaptic PFs and GluD2 at the postsynaptic site. The NRX/Cbln1/GluD2 tripartite complex is resistant to low extracellular Ca2+ levels and serves as a unique bidirectional synaptic organizer.

引用

页码：215 / 220

页数：6

共 49 条

[31] Distinct expression of Cbln family mRNAs in developing and adult mouse brains [J].

Miura, Eriko ;

Iijima, Takatoshi ;

Yuzaki, Michisuke ;

Watanabe, Masahiko .

EUROPEAN JOURNAL OF NEUROSCIENCE, 2006, 24 (03) :750-760

[32] Cbln1 accumulates and colocalizes with Cbln3 and GluRδ2 at parallel fiber-Purkinje cell synapses in the mouse cerebellum [J].

Miura, Eriko ;

Matsuda, Keiko ;

Morgan, James I. ;

Yuzaki, Michisuke ;

Watanabe, Masahiko .

EUROPEAN JOURNAL OF NEUROSCIENCE, 2009, 29 (04) :693-706

[33] Lonotropic glutamate-like receptor δ2 binds D-serine and glycine [J].

Naur, Peter ;

Hansen, Kasper B. ;

Kristensen, Anders S. ;

Dravid, Shashank M. ;

Pickering, Darryl S. ;

Olsen, Lars ;

Vestergaard, Bente ;

Egebjerg, Jan ;

Gajhede, Michael ;

Traynelis, Stephen F. ;

Kastrup, Jette S. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (35) :14116-14121

[34] Expression of neurexin Iα splice variants in sympathetic neurons:: Selective changes during differentiation and in response to neurotrophins [J].

Patzke, H ;

Ernsberger, U .

MOLECULAR AND CELLULAR NEUROSCIENCE, 2000, 15 (06) :561-572

[35] Common polygenic variation contributes to risk of schizophrenia and bipolar disorder [J].

Purcell, Shaun M. ;

Wray, Naomi R. ;

Stone, Jennifer L. ;

Visscher, Peter M. ;

O'Donovan, Michael C. ;

Sullivan, Patrick F. ;

Sklar, Pamela ;

Ruderfer, Douglas M. ;

McQuillin, Andrew ;

Morris, Derek W. ;

O'Dushlaine, Colm T. ;

Corvin, Aiden ;

Holmans, Peter A. ;

Macgregor, Stuart ;

Gurling, Hugh ;

Blackwood, Douglas H. R. ;

Craddock, Nick J. ;

Gill, Michael ;

Hultman, Christina M. ;

Kirov, George K. ;

Lichtenstein, Paul ;

Muir, Walter J. ;

Owen, Michael J. ;

Pato, Carlos N. ;

Scolnick, Edward M. ;

St Clair, David ;

Williams, Nigel M. ;

Georgieva, Lyudmila ;

Nikolov, Ivan ;

Norton, N. ;

Williams, H. ;

Toncheva, Draga ;

Milanova, Vihra ;

Thelander, Emma F. ;

Sullivan, Patrick ;

Kenny, Elaine ;

Quinn, Emma M. ;

Choudhury, Khalid ;

Datta, Susmita ;

Pimm, Jonathan ;

Thirumalai, Srinivasa ;

Puri, Vinay ;

Krasucki, Robert ;

Lawrence, Jacob ;

Quested, Digby ;

Bass, Nicholas ;

Crombie, Caroline ;

Fraser, Gillian ;

Kuan, Soh Leh ;

Walker, Nicholas .

NATURE, 2009, 460 (7256) :748-752

[36] Mutational analysis of the neurexin/neuroligin complex reveals essential and regulatory components [J].

Reissner, Carsten ;

Klose, Martin ;

Fairless, Richard ;

Missler, Markus .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (39) :15124-15129

[37] Extracellular interactions between GluR2 and N-cadherin in spine regulation [J].

Saglietti, Laura ;

Dequidt, Caroline ;

Kamieniarz, Kinga ;

Rousset, Marie-Claude ;

Valnegri, Pamela ;

Thoumine, Olivier ;

Beretta, Francesca ;

Fagni, Laurent ;

Choquet, Daniel ;

Sala, Carlo ;

Sheng, Morgan ;

Passafaro, Maria .

NEURON, 2007, 54 (03) :461-477

[38]

Schell MJ, 1997, J NEUROSCI, V17, P1604

[39] Interaction of the N-terminal domain of the AMPA receptor GIuR4 subunit with the neuronal pentraxin NP1 mediates GluR4 synaptic recruitment [J].

Sia, Gek-Ming ;

Beique, Jean-Claude ;

Rumbaugh, Gavin ;

Cho, Richard ;

Worley, Paul F. ;

Huganir, Richard L. .

NEURON, 2007, 55 (01) :87-102

[40] LRRTMs and Neuroligins Bind Neurexins with a Differential Code to Cooperate in Glutamate Synapse Development [J].

Siddiqui, Tabrez J. ;

Pancaroglu, Raika ;

Kang, Yunhee ;

Rooyakkers, Amanda ;

Craig, Ann Marie .

JOURNAL OF NEUROSCIENCE, 2010, 30 (22) :7495-7506

← 1 2 3 4 5 →