Cbln1 and its family proteins in synapse formation and maintenance

被引：54

作者：

Yuzaki, Michisuke ^{[1
]}

机构：

[1] Keio Univ, Dept Neurophysiol, Sch Med, Shinjuku Ku, Tokyo 1608582, Japan

来源：

CURRENT OPINION IN NEUROBIOLOGY | 2011年 / 21卷 / 02期

基金：

日本科学技术振兴机构;

关键词：

DELTA-2; GLUTAMATE-RECEPTOR; CELL-ADHESION; D-SERINE; DISTINCT EXPRESSION; NMDA RECEPTORS; MESSENGER-RNAS; EPHB RECEPTORS; CEREBELLUM; NEUREXIN; DIFFERENTIATION;

D O I：

10.1016/j.conb.2011.01.010

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Cbln1 is a newly identified synaptic organizer belonging to the C1q family. Unlike other synaptic organizers, a deficiency in Cbln1 is sufficient to cause a severe reduction in the number of synapses between cerebellar Purkinje cells and parallel fibers (PFs). Furthermore, Cbln1 can rapidly induce synaptogenesis and is necessary for maintaining normal synapses in the mature cerebellum in vivo. Cbln1 was recently identified as the missing ligand for the orphan glutamate receptor delta 2 (GluD2), which is expressed in Purkinje cells. Furthermore, Cbln1 released from PFs binds to neurexin (NRX) expressed on the presynaptic PFs and GluD2 at the postsynaptic site. The NRX/Cbln1/GluD2 tripartite complex is resistant to low extracellular Ca2+ levels and serves as a unique bidirectional synaptic organizer.

引用

页码：215 / 220

页数：6

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