Extractive biocatalysis: a powerful tool in selectivity control in yeast biotransformations

被引：46

作者：

D'Arrigo, P

Fuganti, C

Fantoni, GP

Servi, S

机构：

[1] Politecn Milan, Ctr Studio Sostanze Organ Nat, CNR, I-20131 Milan, Italy

[2] Politecn Milan, Dipartimento Chim, I-20131 Milan, Italy

来源：

TETRAHEDRON | 1998年 / 54卷 / 49期

关键词：

baker's yeast; reduction; absorbing resins; in situ product removal;

D O I：

10.1016/S0040-4020(98)00941-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The effect of absorbing resins on the yeast reduction of cl,P-unsaturated carbonyl compounds is reported. Enantioselectivity, chemoselectivity and space-time yields of the biotransformation are impressively enhanced. The distribution of substrates and products between the resin and the water phase shows that the improved selectivity has to be attributed to the control of substrate concentration, (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：15017 / 15026

页数：10

共 27 条

[1] APPLICATION OF A PRACTICAL BIOCATALYTIC REDUCTION TO AN ENANTIOSELECTIVE SYNTHESIS OF THE 5H-2,3-BENZODIAZEPINE LY300164
ANDERSON, BA
HANSEN, MM
HARKNESS, AR
HENRY, CL
VICENZI, JT
ZMIJEWSKI, MJ
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1995, 117 (49) : 12358 - 12359
[2] ANDERSON BA, P CHIR US 98 MAY 18
[3] ARENS CL, 1956, J CHEM SOC, P2987
[4] BOMMARIUS A, 1998, P ADV IND BIOC INB E
[5] ENANTIOMERIC RECOGNITION OF ORGANIC AMMONIUM-SALTS BY CHIRAL DIALKYL-SUBSTITUTED, DIALKENYL-SUBSTITUTED, AND TETRAMETHYL-SUBSTITUTED PYRIDINO-18-CROWN-6 AND TETRAMETHYL-SUBSTITUTED BIS-PYRIDINO-18-CROWN-6 LIGANDS - COMPARISON OF TEMPERATURE-DEPENDENT H-1-NMR AND EMPIRICAL FORCE-FIELD TECHNIQUES
BRADSHAW, JS
HUSZTHY, P
MCDANIEL, CW
ZHU, CY
DALLEY, NK
IZATT, RM
LIFSON, S
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1990, 55 (10) : 3129 - 3137
[6] SYNTHESIS AND RESOLUTION OF THE NOVEL APPETITE-SUPPRESSANT 2-BENZYLMORPHOLINE, A NONSTIMULANT ISOMER OF PHENMETRAZINE
BROWN, GR
FORSTER, G
FOUBISTER, AJ
STRIBLING, D
[J]. JOURNAL OF PHARMACY AND PHARMACOLOGY, 1990, 42 (11) : 797 - 799
[7] STEREOCHEMICAL CONTROL OF YEAST REDUCTIONS .2. QUANTITATIVE TREATMENT OF THE KINETICS OF COMPETING ENZYME-SYSTEMS FOR A SINGLE SUBSTRATE
CHEN, CS
ZHOU, BN
GIRDAUKAS, G
SHIEH, WR
VANMIDDLESWORTH, F
GOPALAN, AS
SIH, CJ
[J]. BIOORGANIC CHEMISTRY, 1984, 12 (02) : 98 - 117
[8] The effect of absorbing resins on substrate concentration and enantiomeric excess in yeast reduction
DArrigo, P
Fantoni, GP
Servi, S
Strini, A
[J]. TETRAHEDRON-ASYMMETRY, 1997, 8 (14) : 2375 - 2379
[9] ECKERT G, 1987, APPL MICROBIOL BIOT, V27, P221
[10] EDENS A, 1955, ORG SYNTH COLL, V3, P731

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