Cellular and molecular mechanisms of estrogen regulation of memory function and neuroprotection against Alzheimer's disease: Recent insights and remaining challenges

被引:142
作者
Brinton, RD [1 ]
机构
[1] Univ So Calif, Dept Mol Pharmacol & Toxicol, Pharmaceut Sci Ctr, Los Angeles, CA 90033 USA
[2] Univ So Calif, Program Neurosci, Pharmaceut Sci Ctr, Los Angeles, CA 90033 USA
关键词
D O I
10.1101/lm.39601
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
This review focuses on recent advances in our knowledge of estrogen action in the brain. The greatest amount of attention was devoted to those studies that impact our understanding of estrogen regulation of memory function and prevention of degenerative diseases associated with memory systems, such as Alzheimer's disease. h review of recent advances in our understanding of estrogen receptors, both nuclear and membrane, is also presented. Finally, these data are considered in regard to their relevancy to the use of estrogen replacement therapy for cognitive health throughout menopause and the development of an estrogen replacement therapy designed for the unique requirements of the brain.
引用
收藏
页码:121 / 133
页数:13
相关论文
共 98 条
[91]  
WILSON ME, 2000, SOC NEUR ABSTR, V1, P3465
[92]  
WISE PM, BIOL REPRO, V63, P982
[93]   PATCH-CLAMP ANALYSIS OF DIRECT STEROIDAL MODULATION OF GLUTAMATE RECEPTOR-CHANNELS [J].
WONG, M ;
MOSS, RL .
JOURNAL OF NEUROENDOCRINOLOGY, 1994, 6 (03) :347-355
[94]  
Woolley CS, 1997, J NEUROSCI, V17, P1848
[95]  
WOOLLEY CS, 1994, J NEUROSCI, V14, P7680
[96]  
Woolley CS, 1999, CRIT REV NEUROBIOL, V13, P1
[97]   Estrogen therapy in postmenopausal women - Effects on cognitive function and dementia [J].
Yaffe, K ;
Sawaya, G ;
Lieberburg, I ;
Grady, D .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1998, 279 (09) :688-695
[98]   NMDA channel regulation by channel-associated protein tyrosine kinase Src [J].
Yu, XM ;
Askalan, R ;
Keil, GJ ;
Salter, MW .
SCIENCE, 1997, 275 (5300) :674-678